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Literature summary extracted from

  • Warrilow, A.G.; Price, C.L.; Parker, J.E.; Rolley, N.J.; Smyrniotis, C.J.; Hughes, D.D.; Thoss, V.; Nes, W.D.; Kelly, D.E.; Holman, T.R.; Kelly, S.L.
    Azole antifungal sensitivity of sterol 14alpha-demethylase (CYP51) and CYP5218 from Malassezia globosa (2016), Sci. Rep., 6, 27690 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.154
-
 Malassezia globosa

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.154 fluconazole
-
 Malassezia globosa
1.14.14.154 itraconazole
-
 Malassezia globosa
1.14.14.154 ketaminazole
-
 Malassezia globosa
1.14.14.154 ketoconazole
-
 Malassezia globosa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.14.154 0.0421
-
 obtusifoliol 37°C, pH 7.2 Malassezia globosa
1.14.14.154 0.0551
-
 lanosterol 37°C, pH 7.2 Malassezia globosa
1.14.14.154 0.0559
-
 eburicol 37°C, pH 7.2 Malassezia globosa

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.154 Malassezia globosa A8Q3I7
-
-
1.14.14.154 Malassezia globosa CBS 7966 A8Q3I7
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.14.154
-
 Malassezia globosa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.154 eburicol + [reduced NADPH-hemoprotein reductase] + O2
-
 Malassezia globosa ?
-
 ?
1.14.14.154 eburicol + [reduced NADPH-hemoprotein reductase] + O2
-
 Malassezia globosa CBS 7966 ?
-
 ?
1.14.14.154 lanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Malassezia globosa ?
-
 ?
1.14.14.154 lanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Malassezia globosa CBS 7966 ?
-
 ?
1.14.14.154 obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
-
 Malassezia globosa ?
-
 ?
1.14.14.154 obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
-
 Malassezia globosa CBS 7966 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.154 CYP51
-
 Malassezia globosa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.14.154 37
-
 assay at Malassezia globosa

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.14.14.154 0.03
-
 lanosterol 37°C, PH 7.2 Malassezia globosa
1.14.14.154 0.06
-
 obtusifoliol 37°C, PH 7.2 Malassezia globosa
1.14.14.154 0.09
-
 eburicol 37°C, PH 7.2 Malassezia globosa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.14.154 7.2
-
 assay at Malassezia globosa

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.14.154 0.176
-
 37°C, pH 7.2 Malassezia globosa ketoconazole
1.14.14.154 0.188
-
 37°C, pH 7.2 Malassezia globosa itraconazole
1.14.14.154 0.206
-
 37°C, pH 7.2 Malassezia globosa fluconazole
1.14.14.154 0.321
-
 37°C, pH 7.2 Malassezia globosa ketaminazole

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.14.14.154 0.54
-
 lanosterol 37°C, pH 7.2 Malassezia globosa
1.14.14.154 1.4
-
 obtusifoliol 37°C, pH 7.2 Malassezia globosa
1.14.14.154 1.6
-
 eburicol 37°C, pH 7.2 Malassezia globosa