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Literature summary extracted from

  • Zheng, J.; Zhang, R.; Chen, Y.; Ye, X.; Chen, Q.; Shen, D.; Wang, Q.
    Synthesis of caffeic acid ester morpholines and their activation effects on tyrosinase (2017), Process Biochem., 62, 91-98 .
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.18.1 2-morpholinoethyl (E)-3-(3,4-dihydroxyphenyl)acrylate a caffeic acid-4-(2-hydroxyethyl) morpholine ester, activates mushroom tyrosinase activity dramatically, the activation of mushroom tyrosinase is noncompetitive Agaricus bisporus
1.14.18.1 2-morpholinoethyl (E)-3-(3,4-dihydroxyphenyl)acrylate a caffeic acid-4-(2-hydroxyethyl) morpholine ester, increases tyrosinase activity in M14 cells in a dose-dependent manner Homo sapiens
1.14.18.1 3-morpholinopropyl (E)-3-(3,4-dihydroxyphenyl)acrylate a caffeic acid-4-(2-hydroxyethyl) morpholine ester, increases tyrosinase activity in M14 cells in a dose-dependent manner Homo sapiens
1.14.18.1 3-morpholinopropyl (E)-3-(3,4-dihydroxyphenyl)acrylate a caffeic acid-4-(3-hydroxypropyl) morpholine ester, activates mushroom tyrosinase activity dramatically the activation of mushroom tyrosinase is noncompetitive Agaricus bisporus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 additional information synthesis of caffeic acid ester morpholines and inhibitory effect on tyrosinase Agaricus bisporus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.18.1 Cu2+ a copper-containing enzyme Agaricus bisporus
1.14.18.1 Cu2+ a copper-containing enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.18.1 2 L-dopa + O2 Agaricus bisporus
-
 2 dopaquinone + 2 H2O
-
 ?
1.14.18.1 2 L-dopa + O2 Homo sapiens
-
 2 dopaquinone + 2 H2O
-
 ?
1.14.18.1 tyrosine + O2 Agaricus bisporus
-
 dopaquinone + H2O
-
 ?
1.14.18.1 tyrosine + O2 Homo sapiens
-
 dopaquinone + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-
1.14.18.1 Homo sapiens P14679
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.1 commercial preparation
-
 Agaricus bisporus
-
1.14.18.1 HL-7702 cell
-
 Homo sapiens
-
1.14.18.1 M14 cell
-
 Homo sapiens
-
1.14.18.1 melanocyte
-
 Homo sapiens
-
1.14.18.1 melanoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 2 L-dopa + O2
-
 Agaricus bisporus 2 dopaquinone + 2 H2O
-
 ?
1.14.18.1 2 L-dopa + O2
-
 Homo sapiens 2 dopaquinone + 2 H2O
-
 ?
1.14.18.1 tyrosine + O2
-
 Agaricus bisporus dopaquinone + H2O
-
 ?
1.14.18.1 tyrosine + O2
-
 Homo sapiens dopaquinone + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 mushroom tyrosinase
-
 Agaricus bisporus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.18.1 30
-
 assay at Agaricus bisporus
1.14.18.1 30
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.18.1 6.8
-
 assay at Agaricus bisporus
1.14.18.1 6.8
-
 assay at Homo sapiens