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Literature summary extracted from

  • Ignea, C.; Athanasakoglou, A.; Ioannou, E.; Georgantea, P.; Trikka, F.A.; Loupassaki, S.; Roussis, V.; Makris, A.M.; Kampranis, S.C.
    Carnosic acid biosynthesis elucidated by a synthetic biology platform (2016), Proc. Natl. Acad. Sci. USA, 113, 3681-3686 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.62 microsome
-
 Salvia pomifera
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.60 Salvia pomifera
-
-
-
1.14.14.61 Salvia pomifera A0A0S1TPC7
-
-
1.14.14.61 Salvia rosmarinus
-
-
-
1.14.14.62 Salvia pomifera A0A0S1TQ04
-
-
1.14.14.175 Salvia pomifera
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.61 trichome glandular trichome Salvia pomifera
-
1.14.14.62 trichome glandular trichome Salvia pomifera
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.60 ferruginol + [reduced NADPH-hemoprotein reductase] + O2
-
 Salvia pomifera 11-hydroxyferruginol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.61 11-hydroxyferruginol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
-
 Salvia rosmarinus carnosic acid + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
 ?
1.14.14.61 11-hydroxyferruginol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
-
 Salvia pomifera carnosic acid + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
 ?
1.14.14.61 ferruginol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
-
 Salvia rosmarinus pisiferic acid + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
 ?
1.14.14.61 ferruginol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
-
 Salvia pomifera pisiferic acid + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
 ?
1.14.14.61 additional information CYP76AK6 is a multifunctional enzyme that catalyzes successive oxidation events at C-20 of the labdane skeleton Salvia rosmarinus ?
-
 ?
1.14.14.61 additional information CYP76AK6 is a multifunctional enzyme that catalyzes successive oxidation events at C-20 of the labdane skeleton Salvia pomifera ?
-
 ?
1.14.14.175 abieta-8,11,13-triene + [reduced NADPH-hemoprotein reductase] + O2 enzyme catalyzes two successive oxidations leading to 11-hydroxyferruginol from abieta-8,11,13-triene, i.e. reactions of EC 1.14.14.175 and 1.14.14.60 Salvia pomifera ferruginol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.175 miltiradiene + [reduced NADPH-hemoprotein reductase] + O2
-
 Salvia pomifera 11-oxomiltiradiene + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.60 CYP76AH24
-
 Salvia pomifera
1.14.14.61 CYP76AK6
-
 Salvia pomifera
1.14.14.61 CYP76AK8
-
 Salvia rosmarinus
1.14.14.62 CYP71BE52
-
 Salvia pomifera
1.14.14.175 CYP76AH24
-
 Salvia pomifera

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.61 cytochrome P450
-
 Salvia rosmarinus
1.14.14.61 cytochrome P450
-
 Salvia pomifera
1.14.14.62 cytochrome P450
-
 Salvia pomifera