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Literature summary extracted from

  • Gandolfi, B.; Grahn, R.A.; Gustafson, N.A.; Proverbio, D.; Spada, E.; Adhikari, B.; Cheng, J.; Andrews, G.; Lyons, L.A.; Helps, C.R.
    A novel variant in CMAH is associated with blood type AB in Ragdoll cats (2016), PLoS ONE, 11, e0154973 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.18.2 DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotyping and genotype-phenotype correlation analysis, genetic variant c.364C>T is highly associated with blood type AB in Ragdoll cats and, to a lesser degree, with type AB in random bred cats, it is associated with the expression of both antigens (N-glycolylneuraminic acid and N-acetylneuraminic acid) on the red blood cell membrane Felis catus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.18.2 CMP-N-acetylneuraminate + 2 ferrocytochrome b5 + O2 + 2 H+ Felis catus
-
 CMP-N-glycoloylneuraminate + 2 ferricytochrome b5 + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.2 Felis catus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.2 erythrocyte
-
 Felis catus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.2 CMP-N-acetylneuraminate + 2 ferrocytochrome b5 + O2 + 2 H+
-
 Felis catus CMP-N-glycoloylneuraminate + 2 ferricytochrome b5 + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.2 CMAH
-
 Felis catus
1.14.18.2 CMP-N-acetylneuraminic acid hydroxylase
-
 Felis catus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.18.2 cytochrome b5
-
 Felis catus

General Information

EC Number General Information Comment Organism
1.14.18.2 evolution CMAH phylogenetic analysis, genotyping and genotype-phenotype correlation analysis of gene CMAH and blood typa A, B, or AB in cat breeds, overview Felis catus
1.14.18.2 malfunction by inactivating enzyme CMAH, the NeuAc precursor accumulates and NeuGc is absent on the erythrocyte cell surface, thus reducing parasite infection in humans and promoting a positive selection during evolution, which results in the enrichment of resistant blood type antigens Felis catus
1.14.18.2 physiological function cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) is associated with the production of the sialic acids present on cat erythrocytes. CMAH converts N-acetylneuraminic acid (NeuAc) to N-glycolylneuraminic acid (NeuGc) by substituting one of the hydrogen atoms in the methyl moiety with a carboxyl group. A genetic variant of enzyme CMAH is associated with blood type AB in Ragdoll cats Felis catus