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Literature summary extracted from

  • Chai, W.M.; Wang, R.; Wei, M.K.; Zou, Z.R.; Deng, R.G.; Liu, W.S.; Peng, Y.Y.
    Proanthocyanidins extracted from Rhododendron pulchrum leaves as source of tyrosinase inhibitors structure, activity, and mechanism (2015), PLoS ONE, 10, e0145483 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 additional information proanthocyanidins extracted from Rhododendron pulchrum fresh leaves, collected from the campus of Jiangxi Normal University (Nanchang, China) in June 2011, are a source of tyrosinase inhibitors, structure, activity, and mechanism, mass spectrometric analysis, overview. Inhibition of monophenolase and diphenolase activity of mushroom tyosinase. Molecular docking of tyrosinase with the ligands using the structure of the oxy tyrosinase from Streptomyces castaneoglobisporus as the initial model for docking simulations Agaricus bisporus
1.14.18.1 procyanidin
-
 Agaricus bisporus
1.14.18.1 prodelphindin
-
 Agaricus bisporus
1.14.18.1 propelargonidin
-
 Agaricus bisporus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.18.1 Cu2+ required for catalysis, binuclear copper center type 3 Agaricus bisporus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.18.1 2 L-dopa + O2 Agaricus bisporus
-
 2 dopaquinone + 2 H2O
-
 ?
1.14.18.1 tyrosine + O2 Agaricus bisporus
-
 dopaquinone + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.1 commercial preparation
-
 Agaricus bisporus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 2 L-dopa + O2
-
 Agaricus bisporus 2 dopaquinone + 2 H2O
-
 ?
1.14.18.1 catechin + O2
-
 Agaricus bisporus ?
-
 ?
1.14.18.1 catechin dimer + O2
-
 Agaricus bisporus ?
-
 ?
1.14.18.1 catechin trimer + O2
-
 Agaricus bisporus ?
-
 ?
1.14.18.1 epicatechin + O2
-
 Agaricus bisporus ?
-
 ?
1.14.18.1 additional information the reactivity, the monomer (catechin/epicatechin) or oligomer (e.g. dimer, trimer) existing in Rhododendron pulchrum proanthocyanidins can take the place of 3,4-dihydroxyphenylalanine Agaricus bisporus ?
-
 ?
1.14.18.1 tyrosine + O2
-
 Agaricus bisporus dopaquinone + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 mushroom tyrosinase
-
 Agaricus bisporus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.18.1 25
-
 assay at Agaricus bisporus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.18.1 6.8
-
 assay at Agaricus bisporus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.18.1 additional information
-
 additional information steady-state inhibition kinetics Agaricus bisporus

General Information

EC Number General Information Comment Organism
1.14.18.1 additional information tyrosinase needs 3,4-dihydroxyphenylalanine to start its monophenol oxidase activity, because of the necessity to reduce Cu2+ to Cu+ because only then the binuclear copper center type 3 of tyrosinase can bind dioxygen to oxidize tyrosine Agaricus bisporus