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Literature summary extracted from

  • Zheng, L.; Tian, H.; Yuan, Y.; Wang, J.
    The influence of endophytic Penicillium oxalicum B4 on growth and artemisinin biosynthesis of in vitro propagated plantlets of Artemisia annua L. (2016), Plant Growth Regul., 80, 93-102 .
No PubMed abstract available

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.114 amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase] Artemisia annua overall reaction via artemsinic alcohol and artemsinic aldehyde, multistep process artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.114 Artemisia annua Q1PS23 cv. CQF39
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.114 additional information callus cannot produce artemisinin Artemisia annua
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1.14.14.114 seedling regenerated plantlets Artemisia annua
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1.14.14.114 trichome artemisinin production in Artemisia annua is localized in glandular trichomes on the surface of leaves, shoots and flowers Artemisia annua
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.114 amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase] overall reaction via artemsinic alcohol and artemsinic aldehyde, multistep process Artemisia annua artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O
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 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.114 amorpha-4,11-diene monooxygenase
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 Artemisia annua
1.14.14.114 CYP71AV1
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 Artemisia annua

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.14.114 7
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 assay at Artemisia annua

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.114 NADPH-hemoprotein reductase A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases, EC 1.14.14._ Artemisia annua

Expression

EC Number Organism Comment Expression
1.14.14.114 Artemisia annua endophyte Penicillium oxalicum strain B4 induces the enzyme and leads to enhanced growth and artemisinin content of host plant in an in vitro dual culture of endophyte with regenerated plantlets via generation of reactive oxygen species (ROS) including superoxide ions and H2O2 up