EC Number | Cloned (Comment) | Organism |
---|---|---|
1.14.14.114 | DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis | Artemisia annua |
1.14.14.114 | DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis | Artemisia afra |
1.14.14.114 | DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis | Artemisia absinthium |
4.2.3.24 | expressed in Escherichia coli BL21-CodonPlus (DE3)-RIL cells | Artemisia annua |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.114 | amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase] | Artemisia annua | - |
artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O | - |
? | |
1.14.14.114 | amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase] | Artemisia afra | - |
artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O | - |
? | |
1.14.14.114 | amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase] | Artemisia absinthium | - |
artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O | - |
? | |
1.14.14.114 | amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase] | Artemisia kurramensis | - |
artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O | - |
? | |
4.2.3.24 | (2E,6E)-farnesyl diphosphate | Artemisia annua | - |
amorpha-4,11-diene + diphosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.14.114 | Artemisia absinthium | K7ZPJ9 | - |
- |
1.14.14.114 | Artemisia afra | K7ZR99 | - |
- |
1.14.14.114 | Artemisia annua | Q1PS23 | - |
- |
1.14.14.114 | Artemisia kurramensis | - |
- |
- |
4.2.3.24 | Artemisia annua | Q9AR04 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.14.114 | leaf | - |
Artemisia annua | - |
1.14.14.114 | leaf | - |
Artemisia afra | - |
1.14.14.114 | leaf | - |
Artemisia absinthium | - |
4.2.3.24 | leaf | - |
Artemisia annua | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.114 | amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase] | - |
Artemisia annua | artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O | - |
? | |
1.14.14.114 | amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase] | - |
Artemisia afra | artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O | - |
? | |
1.14.14.114 | amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase] | - |
Artemisia absinthium | artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O | - |
? | |
1.14.14.114 | amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase] | - |
Artemisia kurramensis | artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O | - |
? | |
4.2.3.24 | (2E,6E)-farnesyl diphosphate | - |
Artemisia annua | amorpha-4,11-diene + diphosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.14.114 | CYP71AV1 | - |
Artemisia annua |
1.14.14.114 | CYP71AV1 | - |
Artemisia afra |
1.14.14.114 | CYP71AV1 | - |
Artemisia absinthium |
1.14.14.114 | CYP71AV1 | - |
Artemisia kurramensis |
4.2.3.24 | ADS | - |
Artemisia annua |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.114 | cytochrome P450 | - |
Artemisia annua | |
1.14.14.114 | cytochrome P450 | - |
Artemisia afra | |
1.14.14.114 | cytochrome P450 | - |
Artemisia absinthium | |
1.14.14.114 | cytochrome P450 | - |
Artemisia kurramensis | |
1.14.14.114 | NADPH-hemoprotein reductase | A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases, EC 1.14.14._ | Artemisia annua | |
1.14.14.114 | NADPH-hemoprotein reductase | A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases, EC 1.14.14._ | Artemisia afra | |
1.14.14.114 | NADPH-hemoprotein reductase | A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases, EC 1.14.14._ | Artemisia absinthium | |
1.14.14.114 | NADPH-hemoprotein reductase | A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases, EC 1.14.14._ | Artemisia kurramensis |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.14.14.114 | metabolism | the enzyme is involved in the artemisinin biosynthesis | Artemisia annua |
1.14.14.114 | metabolism | the enzyme is involved in the artemisinin biosynthesis | Artemisia afra |
1.14.14.114 | metabolism | the enzyme is involved in the artemisinin biosynthesis | Artemisia absinthium |
1.14.14.114 | metabolism | the enzyme is involved in the artemisinin biosynthesis | Artemisia kurramensis |
1.14.14.114 | physiological function | amorpha-4,11-diene 12-monooxygenase (CYP71AV1) catalyzes the multistep oxidation of amorpha-4,11-diene to artemisinic alcohol and artemisinic aldehyde | Artemisia annua |
1.14.14.114 | physiological function | amorpha-4,11-diene 12-monooxygenase (CYP71AV1) catalyzes the multistep oxidation of amorpha-4,11-diene to artemisinic alcohol and artemisinic aldehyde | Artemisia afra |
1.14.14.114 | physiological function | amorpha-4,11-diene 12-monooxygenase (CYP71AV1) catalyzes the multistep oxidation of amorpha-4,11-diene to artemisinic alcohol and artemisinic aldehyde | Artemisia absinthium |
1.14.14.114 | physiological function | amorpha-4,11-diene 12-monooxygenase (CYP71AV1) catalyzes the multistep oxidation of amorpha-4,11-diene to artemisinic alcohol and artemisinic aldehyde | Artemisia kurramensis |