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Literature summary extracted from

  • Lu, X.; Malley, K.R.; Brenner, C.C.; Koroleva, O.; Korolev, S.; Downes, B.P.
    A MUB E2 structure reveals E1 selectivity between cognate ubiquitin E2s in eukaryotes (2016), Nat. Commun., 7, 12580.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.2.1.45 gene UBA1, sequence comparisons Arabidopsis thaliana
6.2.1.45 gene UBA2, sequence comparisons Arabidopsis thaliana

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.2.1.45 AtMUB3 the MUB3 protein of Arabidopsis thaliana strongly reduces the E2-ubiquitin formation by E1. Inhibitory effects of wild-type and mutant MUB3 proteins, overview; the MUB3 protein of Arabidopsis thaliana strongly reduces the E2-ubiquitin formation by E1. Inhibitory effects of wild-type and mutant MUB3 proteins, overview Arabidopsis thaliana
6.2.1.45 additional information Arabidopsis thaliana MUBs1-6 interact specifically with the Arabidopsis thaliana group VI E2 family proteins, MUBs specifically inhibit activation of these critical Ub E2s; Arabidopsis thaliana MUBs1-6 interact specifically with the Arabidopsis thaliana group VI E2 family proteins, MUBs specifically inhibit activation of these critical Ub E2s Arabidopsis thaliana

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.2.1.45 Mg2+ required Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.45 ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine Arabidopsis thaliana
-
 AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.45 Arabidopsis thaliana P92974 UBA2
-
6.2.1.45 Arabidopsis thaliana P93028 UBA1
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.45 ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine
-
 Arabidopsis thaliana AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.2.1.45 AtUBA1
-
 Arabidopsis thaliana
6.2.1.45 AtUBA2
-
 Arabidopsis thaliana
6.2.1.45 E1
-
 Arabidopsis thaliana
6.2.1.45 Ub-activating enzyme
-
 Arabidopsis thaliana
6.2.1.45 Ubiquitin-activating enzyme
-
 Arabidopsis thaliana

Cofactor

EC Number Cofactor Comment Organism Structure
6.2.1.45 ATP
-
 Arabidopsis thaliana

General Information

EC Number General Information Comment Organism
6.2.1.45 evolution MUB inhibition of E1 is conserved between plants and humans Arabidopsis thaliana
6.2.1.45 physiological function ubiquitin-activating enzyme (E1) activates ubiquitin (Ub) conjugating enzyme (E2) Arabidopsis thaliana