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Literature summary extracted from

  • Schenck, C.A.; Chen, S.; Siehl, D.L.; Maeda, H.A.
    Non-plastidic, tyrosine-insensitive prephenate dehydrogenases from legumes (2015), Nat. Chem. Biol., 11, 52-57 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.78 gene ADH1, phylogenetic analysis Arabidopsis thaliana
1.3.1.78 gene ADH2, phylogenetic analysis Arabidopsis thaliana

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.78 L-tyrosine strong inhibition; strong inhibition Arabidopsis thaliana

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.78 chloroplast
-
 Arabidopsis thaliana 9507
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.78 L-arogenate + NADP+ Arabidopsis thaliana
-
 L-tyrosine + NADPH + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.78 Arabidopsis thaliana Q944B6
-
-
1.3.1.78 Arabidopsis thaliana Q9LMR3
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.78 leaf
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.78 L-arogenate + NADP+
-
 Arabidopsis thaliana L-tyrosine + NADPH + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.78 ADH1
-
 Arabidopsis thaliana
1.3.1.78 ADH2
-
 Arabidopsis thaliana
1.3.1.78 arogenate dehydrogenase
-
 Arabidopsis thaliana
1.3.1.78 TyrAa
-
 Arabidopsis thaliana

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.78 NADP+
-
 Arabidopsis thaliana

General Information

EC Number General Information Comment Organism
1.3.1.78 evolution prephenate dehydrogenases (TyrAps, also known as PDHs) from two legumes, Glycine max (soybean) and Medicago truncatula, are phylogenetically distinct from canonical plant ADH enzymes, prefer prephenate to arogenate substrate, localize outside of the plastids and are not inhibited by L-Tyr. Diversification of primary metabolic Tyr pathway via an alternative cytosolic PDH pathway in plants, phylogenetic and biochemical differentiation of ADHs and PDHs Arabidopsis thaliana
1.3.1.78 metabolism in plants, L-Tyr is synthe­sized in the plastids via the arogenate dehydrogenase pathway, in which prephenate is first converted to arogenate by prephenate aminotransferase, EC 2.6.1.7, and then to L-Tyr by enzyme ADH Arabidopsis thaliana