EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
6.2.1.5 | A307V | the mutation is associated with succinyl-CoA ligase (ATP-forming) or succinyl-CoA synthetase (ADP-forming) deficiency | Homo sapiens |
6.2.1.5 | M329V | the mutation is associated with succinyl-CoA ligase (ATP-forming) or succinyl-CoA synthetase (ADP-forming) deficiency | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
6.2.1.5 | 1.33 | - |
succinate | at pH 8.0 and 37°C | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.2.1.5 | ADP + phosphate + succinyl-CoA | Homo sapiens | - |
ATP + succinate + CoA | - |
r | |
6.2.1.5 | ATP + succinate + CoA | Homo sapiens | - |
ADP + phosphate + succinyl-CoA | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
6.2.1.5 | Homo sapiens | Q9P2R7 | subunit beta | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
6.2.1.5 | fibroblast | - |
Homo sapiens | - |
6.2.1.5 | skeletal muscle | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.2.1.5 | ADP + phosphate + succinyl-CoA | - |
Homo sapiens | ATP + succinate + CoA | - |
r | |
6.2.1.5 | ATP + succinate + CoA | - |
Homo sapiens | ADP + phosphate + succinyl-CoA | - |
r |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
6.2.1.5 | A-SCS | - |
Homo sapiens |
6.2.1.5 | ATP-SCS | - |
Homo sapiens |
6.2.1.5 | ATP-succinyl-CoA synthetase | - |
Homo sapiens |
6.2.1.5 | succinyl-CoA ligase (ATP-forming) | - |
Homo sapiens |
6.2.1.5 | Succinyl-CoA synthetase (ADP-forming) | - |
Homo sapiens |
6.2.1.5 | SUCLA2 | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
6.2.1.5 | ADP | - |
Homo sapiens | |
6.2.1.5 | ATP | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
6.2.1.5 | malfunction | enzyme mutations result in succinyl-CoA ligase (ATP-forming) or succinyl-CoA synthetase (ADP-forming) deficiency, a mitochondrial tricarboxylic acid cycle disorder | Homo sapiens |