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Literature summary extracted from

  • Liu, Z.; Huang, Y.; Hu, W.; Huang, S.; Wang, Q.; Han, J.; Zhang, Y.Q.
    dAcsl, the Drosophila ortholog of acyl-CoA synthetase long-chain family member 3 and 4, inhibits synapse growth by attenuating bone morphogenetic protein signaling via endocytic recycling (2014), J. Neurosci., 34, 2785-2796 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.2.1.3 gene ACSL4, recombinant expression in Drosophila melanogaster dAcsl mutant and complementation of reversed distribution of Rab11 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
6.2.1.3 additional information recombinant expression of human gene ACSL4 in Drosophila melanogaster dAcsl mutant and complementation of reversed distribution of Rab11 Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.3 neuromuscular junction
-
 Drosophila melanogaster 31594
-
6.2.1.3 neuromuscular junction
-
 Homo sapiens 31594
-
6.2.1.3 synapse
-
 Drosophila melanogaster 45202
-
6.2.1.3 synapse
-
 Homo sapiens 45202
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.3 ATP + a long-chain carboxylate + CoA Drosophila melanogaster
-
 AMP + diphosphate + an acyl-CoA
-
 ?
6.2.1.3 ATP + a long-chain carboxylate + CoA Homo sapiens
-
 AMP + diphosphate + an acyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.3 Drosophila melanogaster
-
-
-
6.2.1.3 Homo sapiens O60488
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.3 brain
-
 Homo sapiens
-
6.2.1.3 hippocampus high expression level of ACSL4 Homo sapiens
-
6.2.1.3 neuron
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.3 ATP + a long-chain carboxylate + CoA
-
 Drosophila melanogaster AMP + diphosphate + an acyl-CoA
-
 ?
6.2.1.3 ATP + a long-chain carboxylate + CoA
-
 Homo sapiens AMP + diphosphate + an acyl-CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.2.1.3 ACSL4
-
 Homo sapiens
6.2.1.3 acyl-CoA synthetase long-chain
-
 Drosophila melanogaster
6.2.1.3 acyl-CoA synthetase long-chain family member 4
-
 Homo sapiens
6.2.1.3 dAcsl
-
 Drosophila melanogaster

Cofactor

EC Number Cofactor Comment Organism Structure
6.2.1.3 ATP
-
 Drosophila melanogaster
6.2.1.3 ATP
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
6.2.1.3 malfunction dAcsl mutants exhibit neuromuscular junction (NMJ) overgrowth that is suppressed by reducing the doses of the bone morphogenetic protein, BMP, pathway components, accompanied by increased levels of activated BMP receptor Thickveins (Tkv) and phosphorylated mothers against decapentaplegic (Mad), the effector of the BMP signaling at NMJ terminals. In addition, Rab11, a small GTPase involved in endosomal recycling, is mislocalized in dAcsl mutant NMJs, and the membrane association of Rab11 is reduced in dAcsl mutant brains. The staining pattern of Rab11 is markedly alteredin dAcsl mutant NMJs, the abnormal Rab11 localization is specifically caused by dAcsl mutations. Consistently, the BMP receptor Tkv accumulates in early endosomes but is reduced in recycling endosomes in dAcsl mutant NMJs. The level of activated BMP receptor Tkv is elevated in dAcsl mutants. Phenotype, overview. The extended presynaptic distribution of Rab11 is completely reversed by both presynaptic and ubiquitous expression of human ACSL4 Drosophila melanogaster
6.2.1.3 malfunction insights into the pathogenesis of ACSL4-related mental retardation, overview Homo sapiens
6.2.1.3 physiological function ACSL4 regulates neural development, role of ACSL4 in endosomal trafficking in vivo. ACSL4 is highly expressed in the hippocampus, a structure critical for learning and memory. Recombinant expression of human ACSL4 rescues the endocytic trafficking and neuromuscular junction (NMJ) phenotypes of Drosophila melanogaster enzyme mutants of the homologue dAcsl. The extended presynaptic distribution of Rab11 is completely reversed by both presynaptic and ubiquitous expression of human ACSL4 Homo sapiens
6.2.1.3 physiological function dAcsl, the Drosophila orthologue of ACSL4 and ACSL3, inhibits synaptic growth by attenuating bone morphogenetic protein, BMP, signaling, a major growth-promoting pathway at neuromuscular junction (NMJ) synapses. dAcsl is also required for the recycling of photoreceptor rhodopsin in the eyes, implying a general role for dAcsl in regulating endocytic recycling of membrane receptors, dAcsl promotes rhodopsin recycling in photoreceptors, dAcsl inhibits endocytosis of BMP receptors. dAcsl regulates the membrane distribution of Rab11 at NMJs. dAcsl genetically interacts with rab11 in attenuating BMP signaling at NMJ synapses through facilitating Rab11 dependent BMP receptor recycling Drosophila melanogaster