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Literature summary extracted from

  • Yao, Q.; Ma, L.; Liu, L.; Ikeda, H.; Fushinobu, S.; Li, S.; Xu, L.H.
    Hydroxylation of Compactin (ML-236B) by CYP105D7 (SAV_7469) from Streptomyces avermitilis (2017), J. Microbiol. Biotechnol., 27, 956-964 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.15.11 expression in Escheirchia coli Streptomyces avermitilis

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.14.15.11 molecular docking of compactin, compactin is directly hydrogen bonded with residues Thr79, Arg81, Leu178, Thr391, and Ile392 and its C6 position is proximate to the heme group. Molecular docking of diclofenac Streptomyces avermitilis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.15.11 0.039
-
Compactin pH 7.4, 30°C Streptomyces avermitilis
1.14.15.11 0.19
-
diclofenac pH 7.4, 30°C Streptomyces avermitilis

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.11 Streptomyces avermitilis Q825I8
-
-
1.14.15.11 Streptomyces avermitilis DSM 46492 Q825I8
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.11 compactin + reduced ferredoxin + O2
-
Streptomyces avermitilis pravastatin + oxidized ferredoxin + H2O
-
?
1.14.15.11 compactin + reduced ferredoxin + O2
-
Streptomyces avermitilis DSM 46492 pravastatin + oxidized ferredoxin + H2O
-
?
1.14.15.11 compactin + reduced putidaredoxin + O2
-
Streptomyces avermitilis pravastatin + oxidized putidaredoxin + H2O
-
?
1.14.15.11 compactin + reduced putidaredoxin + O2
-
Streptomyces avermitilis DSM 46492 pravastatin + oxidized putidaredoxin + H2O
-
?
1.14.15.11 diclofenac + reduced putidaredoxin + O2
-
Streptomyces avermitilis 4'-hydroxydiclofenac + oxidized putidaredoxin + H2O
-
?
1.14.15.11 diclofenac + reduced putidaredoxin + O2
-
Streptomyces avermitilis DSM 46492 4'-hydroxydiclofenac + oxidized putidaredoxin + H2O
-
?

Subunits

EC Number Subunits Comment Organism
1.14.15.11 ? x * 45000, SDS-PAGE, recombinant protein Streptomyces avermitilis

Synonyms

EC Number Synonyms Comment Organism
1.14.15.11 CYP105D7
-
Streptomyces avermitilis
1.14.15.11 SAV_7469
-
Streptomyces avermitilis

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.14.15.11 0.018
-
Compactin pH 7.4, 30°C Streptomyces avermitilis
1.14.15.11 0.36
-
diclofenac pH 7.4, 30°C Streptomyces avermitilis

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.14.15.11 0.48
-
Compactin pH 7.4, 30°C Streptomyces avermitilis
1.14.15.11 1.9
-
diclofenac pH 7.4, 30°C Streptomyces avermitilis