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Literature summary extracted from

  • Liu, X.; Jia, Y.L.; Chen, J.W.; Liang, G.; Guo, H.Y.; Hu, Y.H.; Shi, Y.; Zhou, H.T.; Chen, Q.X.
    Inhibition effects of benzylideneacetone, benzylacetone, and 4-phenyl-2-butanol on the activity of mushroom tyrosinase (2015), J. Biosci. Bioeng., 119, 275-279 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 4-phenyl-2-butanol a reversible, potent inhibitor of tyrosinase, mixed-type inhibitor fothe monophenoase activity and noncompetitive-type inhibitor for the diphenolase activity Agaricus bisporus
1.14.18.1 benzylacetone a reversible, potent inhibitor of tyrosinase, mixed-type inhibitor Agaricus bisporus
1.14.18.1 benzylideneacetone a reversible, potent inhibitor of tyrosinase, mixed-type inhibitor Agaricus bisporus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.18.1 Cu2+ a copper-containing enzyme Agaricus bisporus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.18.1 2 L-dopa + O2 Agaricus bisporus
-
 2 dopaquinone + 2 H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.1 commercial preparation
-
 Agaricus bisporus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 2 L-dopa + O2
-
 Agaricus bisporus 2 dopaquinone + 2 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 mushroom tyrosinase
-
 Agaricus bisporus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.18.1 additional information
-
 additional information inhibition kinetics, type, and constants, and inhibition mechanism of benzylideneacetone, benzylacetone, and 4-phenyl-2-butanol, overview Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.1 0.6
-
 inhibition of diphenolase activity of the enzyme, pH and temperature not specified in the publication Agaricus bisporus benzylacetone
1.14.18.1 0.8
-
 inhibition of diphenolase activity of the enzyme, pH and temperature not specified in the publication Agaricus bisporus 4-phenyl-2-butanol
1.14.18.1 1.1
-
 inhibition of monophenolase activity of the enzyme, pH and temperature not specified in the publication Agaricus bisporus 4-phenyl-2-butanol
1.14.18.1 1.5
-
 inhibition of monophenolase activity of the enzyme, pH and temperature not specified in the publication Agaricus bisporus benzylideneacetone
1.14.18.1 2
-
 inhibition of diphenolase activity of the enzyme, pH and temperature not specified in the publication Agaricus bisporus benzylideneacetone
1.14.18.1 2.8
-
 inhibition of monophenolase activity of the enzyme, pH and temperature not specified in the publication Agaricus bisporus benzylacetone

General Information

EC Number General Information Comment Organism
1.14.18.1 additional information tyrosinase is a kind of multiple functional oxidase containing di-copper catalytic core Agaricus bisporus