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Literature summary extracted from

  • Silva, P.; De Castro, B.; Hagen, W.
    On the prosthetic groups of the NiFe sulfhydrogenase from Pyrococcus furiosus Topology, structure, and temperature-dependent redox chemistry (1999), J. Biol. Inorg. Chem., 4, 284-291 .
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.12.98.4 Iron the alpha-subunit carries the NiFe dinuclear center Pyrococcus furiosus
1.12.98.4 Nickel the alpha-subunit carries the NiFe dinuclear center Pyrococcus furiosus

Organism

EC Number Organism UniProt Comment Textmining
1.12.98.4 Pyrococcus furiosus E7FI44 AND Q8U2E5 AND Q8U2E4 AND E7FHU4 E7FI44: alpha-subunit, Q8U2E5: beta-subunit, Q8U2E4: gamma-subunit, E7FHU4: delta-subunit
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.12.98.4
-
 Pyrococcus furiosus

Subunits

EC Number Subunits Comment Organism
1.12.98.4 heterotetramer alphabetagammadelta hetreotetramer, 1 * 48700 + 1 * 41800 + 33200 + 29600 Pyrococcus furiosus

Synonyms

EC Number Synonyms Comment Organism
1.12.98.4 NiFe sulfhydrogenase
-
 Pyrococcus furiosus

Cofactor

EC Number Cofactor Comment Organism Structure
1.12.98.4 FAD the gamma-subunit contains one FAD molecule Pyrococcus furiosus
1.12.98.4 [2Fe-2S]-center the gamma-subunit contains one 2Fe-2S cluster Pyrococcus furiosus
1.12.98.4 [4Fe-4S]-center the beta subunit contains at least two [4Fe-4S] cubanes. The delta-subunit contains three [4Fe-4S] cubanes Pyrococcus furiosus
1.12.98.4 [Ni-Fe]-center the alpha-subunit carries the NiFe dinuclear center Pyrococcus furiosus