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Literature summary extracted from

  • Sproviero, D.; Julien, S.; Burford, B.; Taylor-Papadimitriou, J.; Burchell, J.M.
    Cyclooxygenase-2 enzyme induces the expression of the alpha-2,3-sialyltransferase-3 (ST3Gal-I) in breast cancer (2012), J. Biol. Chem., 287, 44490-44497 .
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.4.3.2 Homo sapiens Q11201
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.3.2 MDA-MB-231 cell
-
Homo sapiens
-
2.4.3.2 T-47D cell
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Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.2 CMP-N-acetyl-beta-neuraminate + beta-D-Gal-(1->3)-beta-D-GalNAc
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Homo sapiens CMP + alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GalNAc
-
?

Synonyms

EC Number Synonyms Comment Organism
2.4.3.2 ST3Gal-I
-
Homo sapiens

Expression

EC Number Organism Comment Expression
2.4.3.2 Homo sapiens induction of COX-2 in the MDAMB-231 breast cancer cell line results in the increased expression of ST3Gal-I, leading to increased sialylation of the substrate of ST3Gal-I up
2.4.3.2 Homo sapiens PGE2, one of the final products of the cyclooxygenase-2 (COX-2) pathway, can induce the mRNA expression of the sialyltransferase ST3Gal-I, resulting in increased sialyltransferase activity up