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Literature summary extracted from

  • Higgins, E.A.; Siminovitch, K.A.; Zhuang, D.; Brockhausen, I.; Dennis, J.W.
    Aberrant O-linked oligosaccharide biosynthesis in lymphocytes and platelets from patients with the Wiskott-Aldrich syndrome (1991), J. Biol. Chem., 266, 6280-6290 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.3.4 CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R Homo sapiens the enzyme is involved in O-linked glycosylation pathway for synthesis of core 1 and core 2 oligosaccharides CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.3.4 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.3.4 lymphocyte T-lymphocytes, Epstein-Barr virus immortalized B-lymphocytes Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.4 CMP-N-acetylneuraminate + 4-nitrophenyl beta-D-Gal-(1->3)-alpha-D-GalNAc
-
 Homo sapiens CMP + 4-nitrophenyl alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc
-
 ?
2.4.3.4 CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R the enzyme is involved in O-linked glycosylation pathway for synthesis of core 1 and core 2 oligosaccharides Homo sapiens CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.3.4 alpha3SA-T
-
 Homo sapiens
2.4.3.4 CMP-SA:Gal63GalNAc-R alpha3-sialyltransferase (SA to Gal)
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.3.4 7
-
 assay at Homo sapiens