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Literature summary extracted from

  • Ma, D.; Li, G.; Zhu, Y.; Xie, D.
    Overexpression and suppression of Artemisia annua 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1 gene (AaHDR1) differentially regulate artemisinin and terpenoid biosynthesis (2017), Front. Plant Sci., 8, doi: 10.3389/fpls.2017.00077 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.17.7.4 chloroplast
-
 Artemisia annua 9507
-
1.17.7.4 plastid
-
 Artemisia annua 9536
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.7.4 (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+ Artemisia annua
-
 dimethylallyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?
1.17.7.4 (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+ Artemisia annua
-
 isopentenyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.7.4 Artemisia annua A0A1V0C086
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.7.4 flower
-
 Artemisia annua
-
1.17.7.4 leaf highest expression Artemisia annua
-
1.17.7.4 root
-
 Artemisia annua
-
1.17.7.4 stem
-
 Artemisia annua
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.7.4 (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+
-
 Artemisia annua dimethylallyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?
1.17.7.4 (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+
-
 Artemisia annua isopentenyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
1.17.7.4 ? x * 51405, calculated from amino acid sequence Artemisia annua

Synonyms

EC Number Synonyms Comment Organism
1.17.7.4 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1
-
 Artemisia annua
1.17.7.4 4-hydroxy-3-methylbut-2-enyl pyrophosphate reductase
-
 Artemisia annua
1.17.7.4 HDR1
-
 Artemisia annua
1.17.7.4 isoprenoid synthesis H
-
 Artemisia annua
1.17.7.4 ispH
-
 Artemisia annua
1.17.7.4 lysis-tolerant B
-
 Artemisia annua
1.17.7.4 LytB
-
 Artemisia annua

pI Value

EC Number Organism Comment pI Value Maximum pI Value
1.17.7.4 Artemisia annua calculated from amino acid sequence
-
 5.6

General Information

EC Number General Information Comment Organism
1.17.7.4 metabolism enzyme overexpression leads to the increase of artemisinin production Artemisia annua