Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Tiedt, O.; Mergelsberg, M.; Eisenreich, W.; Boll, M.
    Promiscuous defluorinating enoyl-CoA hydratases/hydrolases allow for complete anaerobic degradation of 2-fluorobenzoate (2017), Front. Microbiol., 8, 2579-2589 .
    View publication on PubMedView publication on EuropePMC

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.2.1.25 Mg2+ required Thauera aromatica

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.25 ATP + 2-fluorobenzoate + CoA Thauera aromatica activation of 2-fluorobenzoate by promiscuous AMP-forming benzoate-CoA ligase AMP + diphosphate + 2-fluorobenzoyl-CoA
-
 ?
6.2.1.25 ATP + benzoate + CoA Thauera aromatica
-
 AMP + diphosphate + benzoyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.25 Thauera aromatica Q8GQN9
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.25 ATP + 2-fluorobenzoate + CoA activation of 2-fluorobenzoate by promiscuous AMP-forming benzoate-CoA ligase Thauera aromatica AMP + diphosphate + 2-fluorobenzoyl-CoA
-
 ?
6.2.1.25 ATP + benzoate + CoA
-
 Thauera aromatica AMP + diphosphate + benzoyl-CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.2.1.25 AMP-forming BCL
-
 Thauera aromatica
6.2.1.25 AMP-forming benzoate-CoA ligase
-
 Thauera aromatica
6.2.1.25 Bcl
-
 Thauera aromatica
6.2.1.25 bclA
-
 Thauera aromatica
6.2.1.25 benzoate-CoA ligase
-
 Thauera aromatica

Cofactor

EC Number Cofactor Comment Organism Structure
6.2.1.25 ATP
-
 Thauera aromatica

General Information

EC Number General Information Comment Organism
6.2.1.25 metabolism the enzyme is involved in oxygen-independent defluorination and degradation of 2-fluorobenzoate to CO2 and HF, pathway overview. BCL readily activates 2-fluorobenzoate to 2-fluorobenzoyl-CoA at a rate similar to that of benzoate suggesting that 2-fluorobenzoate metabolism is initiated by CoA thioester formation Thauera aromatica