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Literature summary extracted from

  • Borcea, A.; Marc, G.; Pirnau, A.; Vlase, L.; Ionut, I.; Tiperciuc, B.; Oniga, O.
    Synthesis and molecular docking study of some new 1,4-phenylene-bisthiazoles as fungal lanosterol 14alpha-demethylase inhibitors (2017), Farmacia, 65, 683-689 .
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.154 1-(4-methyl-2-(4-(2-methylthiazol-4-yl)phenyl)thiazol-5-yl)ethanone the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study Candida albicans SC5314
1.14.14.154 2-hydroxy-5-(2-(4-(2-methylthiazol-4-yl)phenyl)thiazol-4-yl)benzamide the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study Candida albicans SC5314
1.14.14.154 2-methyl-4-(4-(4-(naphthalen-1-yl)thiazol-2-yl)phenyl)-thiazole the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study Candida albicans SC5314
1.14.14.154 2-methyl-4-(4-(4-phenylthiazol-2-yl)phenyl)thiazole the compounds is predicted to be a non-competitive inhibitors of the enzyme by molecular docking study Candida albicans SC5314
1.14.14.154 4-(2-(4-(2-methylthiazol-4-yl)phenyl)thiazol-4-yl)-benzonitrile the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study Candida albicans SC5314
1.14.14.154 4-(4-chlorophenyl)-2-(4-(2-methylthiazol-4-yl)phenyl)-thiazole the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study Candida albicans SC5314
1.14.14.154 4-(4-methoxyphenyl)-2-(4-(2-methylthiazol-4-yl)-phenyl)thiazole the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study Candida albicans SC5314
1.14.14.154 4-(chloromethyl)-2-(4-(2-methylthiazol-4-yl)phenyl)-thiazole the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study Candida albicans SC5314
1.14.14.154 ethyl 2-(2-(4-(2-methylthiazol-4-yl)phenyl)thiazol-4-yl)acetate the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study Candida albicans SC5314
1.14.14.154 ethyl 4-methyl-2-(4-(2-methylthiazol-4-yl)phenyl)-thiazole-5-carboxylate the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study Candida albicans SC5314

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.154 Candida albicans SC5314 P10613
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