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Literature summary extracted from
- Development of an immunoassay for the kidney-specific protein myo-inositol oxygenase, a potential biomarker of acute kidney injury (2014), Clin. Chem., 60, 747-757 .
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.13.99.1 | diagnostics | the kidney-specific protein myo-inositol oxygenase is a potential biomarker of acute kidney injury, AKI | Homo sapiens |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.13.99.1 | gene MIOX, kidney-specific expression, recombinant expression of GST-tagged enzyme in HEK-293 cells, cleavage of the GST tag by thrombin | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.13.99.1 | myo-inositol + O2 | Mus musculus | - |
D-glucuronate + H2O | - |
? |  |
| 1.13.99.1 | myo-inositol + O2 | Homo sapiens | - |
D-glucuronate + H2O | - |
? | |
| 1.13.99.1 | myo-inositol + O2 | Mus musculus C57BL/6 | - |
D-glucuronate + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.13.99.1 | Homo sapiens | Q9UGB7 | - |
- |
| 1.13.99.1 | Mus musculus | Q9QXN5 | - |
- |
| 1.13.99.1 | Mus musculus C57BL/6 | Q9QXN5 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.13.99.1 | blood plasma | from mice with acute kidney injury, MIOX expression is undetectable in healthy mice plasma | Mus musculus | - |
| 1.13.99.1 | blood plasma | plasma MIOX is increased in critically ill patients with acute kidney injury compared with patients without acute kidney injury and is highest in patients with oliguric acute kidney injury | Homo sapiens | - |
| 1.13.99.1 | kidney | kidney-specific expression of protein myo-inositol oxygenase encoding gene miox in proximal renal tubule | Mus musculus | - |
| 1.13.99.1 | kidney | kidney-specific expression of protein myo-inositol oxygenase encoding gene miox in proximal renal tubule | Homo sapiens | - |
| 1.13.99.1 | additional information | immunohistochemic analysis | Mus musculus | - |
| 1.13.99.1 | additional information | immunohistochemic analysis | Homo sapiens | - |
| 1.13.99.1 | renal proximal tubule | - |
Mus musculus | - |
| 1.13.99.1 | renal proximal tubule | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.13.99.1 | myo-inositol + O2 | - |
Mus musculus | D-glucuronate + H2O | - |
? | |
| 1.13.99.1 | myo-inositol + O2 | - |
Homo sapiens | D-glucuronate + H2O | - |
? | |
| 1.13.99.1 | myo-inositol + O2 | - |
Mus musculus C57BL/6 | D-glucuronate + H2O | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.13.99.1 | ? | x * 37000, recombinant detagged enzyme, SDS-PAGE | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.13.99.1 | MIOX | - |
Mus musculus |
| 1.13.99.1 | MIOX | - |
Homo sapiens |
| 1.13.99.1 | Myo-inositol oxygenase | - |
Mus musculus |
| 1.13.99.1 | Myo-inositol oxygenase | - |
Homo sapiens |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.13.99.1 | physiological function | kidney-specific expression of myo-inositol oxygenase in acute kidney injury | Mus musculus |
| 1.13.99.1 | physiological function | MIOX is a renal specific, proximal tubule protein that is increased in plasma ofanimals and critically ill patients with acute kidney injury, AKI. MIOX preceds the elevation in SCr by approximately two days in human patients | Homo sapiens |
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