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Literature summary extracted from

  • Yin, Y.; Yu, H.; Luan, Z.; Li, R.; Ouyang, P.; Liu, J.; Xu, J.
    Unusually broad substrate profile of self-sufficient Cytochrome P450 monooxygenase CYP116B4 from Labrenzia aggregata (2014), ChemBioChem, 15, 2443-2449 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.1 expression in Escherichia coli Roseibium aggregatum

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.1 Roseibium aggregatum A0P0F6
-
-
1.14.14.1 Roseibium aggregatum DSM 13394 A0P0F6
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.1 (methylsulfanyl)benzene + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
 Roseibium aggregatum methyl(phenyl)sulfaniumolate + [oxidized NADPH-hemoprotein reductase] + ?
-
 ?
1.14.14.1 (methylsulfanyl)benzene + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
 Roseibium aggregatum DSM 13394 methyl(phenyl)sulfaniumolate + [oxidized NADPH-hemoprotein reductase] + ?
-
 ?
1.14.14.1 1-chloro-4-(methylsulfanyl)benzene + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
 Roseibium aggregatum (4-chlorophenyl)(methyl)sulfaniumolate + [oxidized NADPH-hemoprotein reductase] + ?
-
 ?
1.14.14.1 1-chloro-4-(methylsulfanyl)benzene + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
 Roseibium aggregatum DSM 13394 (4-chlorophenyl)(methyl)sulfaniumolate + [oxidized NADPH-hemoprotein reductase] + ?
-
 ?
1.14.14.1 1-chloro-4-ethenylbenzene + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
 Roseibium aggregatum (4-chlorophenyl)acetaldehyde + 2-(4-chlorophenyl)oxirane + 2-(4-chlorophenyl)ethan-1-ol + [oxidized NADPH-hemoprotein reductase] + ?
-
 ?
1.14.14.1 1-chloro-4-ethenylbenzene + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
 Roseibium aggregatum DSM 13394 (4-chlorophenyl)acetaldehyde + 2-(4-chlorophenyl)oxirane + 2-(4-chlorophenyl)ethan-1-ol + [oxidized NADPH-hemoprotein reductase] + ?
-
 ?
1.14.14.1 1-methoxy-4-(methylsulfanyl)benzene + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
 Roseibium aggregatum (4-methoxyphenyl)(methyl)sulfaniumolate + [oxidized NADPH-hemoprotein reductase] + ?
-
 ?
1.14.14.1 1-methoxy-4-(methylsulfanyl)benzene + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
 Roseibium aggregatum DSM 13394 (4-methoxyphenyl)(methyl)sulfaniumolate + [oxidized NADPH-hemoprotein reductase] + ?
-
 ?
1.14.14.1 2,3-dihydroindene + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
 Roseibium aggregatum (1S)-2,3-dihydroinden-1-ol + 2,3-dihydroinden-1-one + [oxidized NADPH-hemoprotein reductase] + ?
-
 ?
1.14.14.1 4-chlorothioanisole + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
 Roseibium aggregatum 4-chlorothioanisole sulfoxide + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.1 4-nitroanisole + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
 Roseibium aggregatum 4-nitrophenol + [oxidized NADPH-hemoprotein reductase] + ?
-
 ?
1.14.14.1 7-ethoxycoumarin + [reduced NADPH-hemoprotein reductase] + H+
-
 Roseibium aggregatum coumarin + [oxidized NADPH-hemoprotein reductase] + ?
-
 ?
1.14.14.1 7-methoxycoumarin + [reduced NADPH-hemoprotein reductase] + H+
-
 Roseibium aggregatum coumarin + [oxidized NADPH-hemoprotein reductase] + ?
-
 ?
1.14.14.1 cytochrome c + O2 + NADH
-
 Roseibium aggregatum ? + NAD+ + ?
-
 ?
1.14.14.1 ethylbenzene + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
 Roseibium aggregatum (1S)-1-phenylethan-1-ol + 1-phenylethan-1-one + [oxidized NADPH-hemoprotein reductase] + ?
-
 ?
1.14.14.1 indene + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
 Roseibium aggregatum (S)-inden-1-ol + 2,3-dihydroinden-1-one + [oxidized NADPH-hemoprotein reductase] + ?
-
 ?
1.14.14.1 additional information versatile catalyst, exhibiting hydroxylation and epoxidation activities as well as O-dealkylation and asymmetric sulfoxidation activities. Alkylbenzenes, aromatic bicyclic molecules, and terpenoids are hydroxylated by Cyp116B4 Roseibium aggregatum ?
-
 ?
1.14.14.1 additional information versatile catalyst, exhibiting hydroxylation and epoxidation activities as well as O-dealkylation and asymmetric sulfoxidation activities. Alkylbenzenes, aromatic bicyclic molecules, and terpenoids are hydroxylated by Cyp116B4 Roseibium aggregatum DSM 13394 ?
-
 ?
1.14.14.1 toluene + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
 Roseibium aggregatum benzylalcohol + benzaldehyde + [oxidized NADPH-hemoprotein reductase] + ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.14.14.1 ? x * 87000, SDS-PAGE Roseibium aggregatum

Synonyms

EC Number Synonyms Comment Organism
1.14.14.1 CYP116B4
-
 Roseibium aggregatum
1.14.14.1 SIAM614_30676
-
 Roseibium aggregatum

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.1 cytochrome P450
-
 Roseibium aggregatum
1.14.14.1 FMN
-
 Roseibium aggregatum
1.14.14.1 NADH NADPH is preferred over NADH Roseibium aggregatum
1.14.14.1 NADPH NADPH is preferred over NADH Roseibium aggregatum
1.14.14.1 [2Fe-2S]-center
-
 Roseibium aggregatum