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Literature summary extracted from

  • Wang, R.; Chai, W.M.; Yang, Q.; Wei, M.K.; Peng, Y.
    2-(4-Fluorophenyl)-quinazolin-4(3H)-one as a novel tyrosinase inhibitor Synthesis, inhibitory activity, and mechanism (2016), Bioorg. Med. Chem., 24, 4620-4625 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 2-(4-fluorophenyl)-quinazolin-4(3H)-one synthesis of the tyrosinase inhibitor, inhibits the diphenolase activity of tyrosinase. Structure analysis by 1H and 13C NMR spectroscopy, Fourier transform infrared spectroscopy (FTIR), and high resolution mass spectrometry. Molecular docking simulation analysis and inhibition mechanism, a mixed-type inhibitor exerting reversible inhibition, overview. The inhibitor does not reduce the amount of the enzyme, but decreases the enzyme activity for the oxidation of L-dopa Agaricus bisporus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.18.1 Cu2+ a copper-containing enzyme Agaricus bisporus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.18.1 2 L-dopa + O2 Agaricus bisporus
-
 2 dopaquinone + 2 H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.1 commercial preparation
-
 Agaricus bisporus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 2 L-dopa + O2
-
 Agaricus bisporus 2 dopaquinone + 2 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 mushroom tyrosinase
-
 Agaricus bisporus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.18.1 additional information
-
 additional information inhibition kinetic analysis, overview Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.1 0.12
-
 pH and temperature not specified in the publication Agaricus bisporus 2-(4-fluorophenyl)-quinazolin-4(3H)-one