Literature summary extracted from

Songserm, P.; Thitiprasert, S.; Tolieng, V.; Piluk, J.; Tanasupawat, S.; Assabumrungrat, S.; Yang, S.T.; Karnchanatat, A.; Thongchul, N.
Regulating pyruvate carboxylase in the living culture of Aspergillus terreus Nrrl 1960 by L-aspartate for enhanced itaconic acid production (2015), Appl. Biochem. Biotechnol., 177, 595-609 .

Application

EC Number	Application	Comment	Organism
6.4.1.1	synthesis	the presence of 10 mM L-aspartate in the production medium directly represses pyruvate carboxylase expression. This leads to limited malate flux which in turn regulates the malate/citrate antiporters resulting in increasing cis-aconitate decarboxylase activity to simultaneously convert cis-aconitate, citrate isomer, into itaconic acid	Aspergillus terreus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
6.4.1.1	L-aspartate	allosteric inhibitor	Aspergillus terreus

Organism

EC Number	Organism	UniProt	Comment	Textmining
6.4.1.1	Aspergillus terreus	-	-	-
6.4.1.1	Aspergillus terreus Nrrl 1960	-	-	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)