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Literature summary extracted from

  • Agarwal, V.; Moore, B.
    Enzymatic synthesis of polybrominated dioxins from the marine environment (2014), ACS Chem. Biol., 9, 1980-1984 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.19.55 expression in Escherichia coli Marinomonas mediterranea

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.55 Marinomonas mediterranea
-
-
-
1.14.19.55 Marinomonas mediterranea MMB-1
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.55 2,4-dihydroxybenzoate + 2 NADPH + 2 bromide + 2 O2 + 2 H+
-
 Marinomonas mediterranea 2,4-dibromo-6-hydroxyphenol + 4-bromo-2-hydroxyphenol + 2 NADP+ + CO2 + 4 H2O
-
 ?
1.14.19.55 2,4-dihydroxybenzoate + 2 NADPH + 2 bromide + 2 O2 + 2 H+
-
 Marinomonas mediterranea MMB-1 2,4-dibromo-6-hydroxyphenol + 4-bromo-2-hydroxyphenol + 2 NADP+ + CO2 + 4 H2O
-
 ?
1.14.19.55 3,4-dihydroxybenzoate + 2 NADPH + 2 bromide + 2 O2 + 2 H+
-
 Marinomonas mediterranea 2,4-dibromo-6-hydroxyphenol + 4-bromo-2-hydroxyphenol + 2 NADP+ + CO2 + 4 H2O
-
 ?
1.14.19.55 3,4-dihydroxybenzoate + 2 NADPH + 2 bromide + 2 O2 + 2 H+
-
 Marinomonas mediterranea MMB-1 2,4-dibromo-6-hydroxyphenol + 4-bromo-2-hydroxyphenol + 2 NADP+ + CO2 + 4 H2O
-
 ?
1.14.19.55 4-hydroxybenzoate + 2 NADPH + 2 bromide + 2 O2 + 2 H+
-
 Marinomonas mediterranea 2,4-dibromophenol + 2 NADP+ + CO2 + 4 H2O
-
 ?
1.14.19.55 4-hydroxybenzoate + 2 NADPH + 2 bromide + 2 O2 + 2 H+
-
 Marinomonas mediterranea MMB-1 2,4-dibromophenol + 2 NADP+ + CO2 + 4 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.55 bmp5
-
 Marinomonas mediterranea

General Information

EC Number General Information Comment Organism
1.14.19.55 physiological function coexpression of Bmp5 with flavin-dependent 4-hydroxybenzoate-3-hydroxylase m3553 in Escherichia coli yields 2,4-dibromophenol, 4-bromo-2-hydroxyphenol and 2,4-dibromo-6-hydroxyphenol. Coexpression of Bmp5, Cyp450 enzyme Bmp7, and m3553, and supplementation of the culture medium with exogenous 4-hydroxybenzoic acid, leads to production of bromophenols, bromocatechols, mono- and dihydroxylated dibenzo-p-dioxins, mono- and dihydroxy-brominated diphenyl ethers, as well as biphenyls Marinomonas mediterranea