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Literature summary extracted from

  • Gao, J.L.; Weissenmayer, B.; Taylor, A.M.; Thomas-Oates, J.; Lopez-Lara, I.M.; Geiger, O.
    Identification of a gene required for the formation of lyso-ornithine lipid, an intermediate in the biosynthesis of ornithine-containing lipids (2004), Mol. Microbiol., 53, 1757-1770 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.2.30 expressed in Escherichia coli BL21(DE3) cells and in an olsA-deficient mutant of Sinorhizobium meliloti Sinorhizobium meliloti

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.270 a lyso-ornithine lipid + an acyl-[acyl-carrier protein] Sinorhizobium meliloti
-
 an ornithine lipid + a holo-[acyl-carrier protein]
-
 ?
2.3.2.30 L-ornithine + a (3R)-3-hydroxyacyl-[acyl-carrier protein] Sinorhizobium meliloti
-
 a lyso-ornithine lipid + a holo-[acyl-carrier protein]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.270 Sinorhizobium meliloti
-
-
-
2.3.2.30 Sinorhizobium meliloti
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.270 a lyso-ornithine lipid + an acyl-[acyl-carrier protein]
-
 Sinorhizobium meliloti an ornithine lipid + a holo-[acyl-carrier protein]
-
 ?
2.3.2.30 L-ornithine + (3R)-3-hydroxyacyl-[palmitoyl-carrier protein]
-
 Sinorhizobium meliloti a lyso-ornithine lipid + holo-[palmitoyl-carrier protein]
-
 ?
2.3.2.30 L-ornithine + a (3R)-3-hydroxyacyl-[acyl-carrier protein]
-
 Sinorhizobium meliloti a lyso-ornithine lipid + a holo-[acyl-carrier protein]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.270 olsA
-
 Sinorhizobium meliloti
2.3.2.30 L-ornithine Nalpha-acyltransferase
-
 Sinorhizobium meliloti
2.3.2.30 olsB
-
 Sinorhizobium meliloti

General Information

EC Number General Information Comment Organism
2.3.2.30 metabolism the enzyme is is required for the first step of ornithine-containing lipid biosynthesis. Enzyme overexpression in Escherichia coli is sufficient to cause the in vivo formation of lyso-ornithine lipid in this organism and is the cause for a (3R)-3-hydroxyacyl-[acyl-carrier protein]-dependent acyltransferase activity forming lyso-ornithine lipid from ornithine Sinorhizobium meliloti