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Literature summary extracted from

  • Pecsi, I.; Hards, K.; Ekanayaka, N.; Berney, M.; Hartman, T.; Jacobs, W.R.; Cook, G.M.
    Essentiality of succinate dehydrogenase in Mycobacterium smegmatis and its role in the generation of the membrane potential under hypoxia (2014), mBio, 5, e01093 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.5.1 3-nitropropanoate treatment with 3-nitroproprionate dissipates the membrane potential of wild-type or Sdh1 mutant cells under hypoxia but not that of cells grown aerobically Mycolicibacterium smegmatis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.5.1 membrane
-
Mycolicibacterium smegmatis 16020
-

Organism

EC Number Organism UniProt Comment Textmining
1.3.5.1 Mycolicibacterium smegmatis A0QPJ1 and A0QPJ2 and A0QPJ3 and A0QPJ4 and A0QPJ5 isoform Sdh1 is encoded by a five-gene operon. A0QPJ1 i.e. gene MSMEG_0416, A0QPJ2 i.e. gene MSMEG_0417, A0QPJ3 i.e. gene MSMEG_0418, A0QPJ4 i.e. gene MSMEG_0419, A0QPJ5 i.e. gene MSMEG_0420
-
1.3.5.1 Mycolicibacterium smegmatis A0QT07 and A0QT08 and A0QT09 and A0QT10 isoform Sdh2 is encoded by a five-gene operon. A0QT07 i.e. gene MSMEG_1669, A0QT08 i.e. gene MSMEG_1670, A0QT09 i.e. gene MSMEG_1671, A0QT10 i.e. gene MSMEG_1672
-
1.3.5.1 Mycolicibacterium smegmatis ATCC 700084 A0QPJ1 and A0QPJ2 and A0QPJ3 and A0QPJ4 and A0QPJ5 isoform Sdh1 is encoded by a five-gene operon. A0QPJ1 i.e. gene MSMEG_0416, A0QPJ2 i.e. gene MSMEG_0417, A0QPJ3 i.e. gene MSMEG_0418, A0QPJ4 i.e. gene MSMEG_0419, A0QPJ5 i.e. gene MSMEG_0420
-
1.3.5.1 Mycolicibacterium smegmatis ATCC 700084 A0QT07 and A0QT08 and A0QT09 and A0QT10 isoform Sdh2 is encoded by a five-gene operon. A0QT07 i.e. gene MSMEG_1669, A0QT08 i.e. gene MSMEG_1670, A0QT09 i.e. gene MSMEG_1671, A0QT10 i.e. gene MSMEG_1672
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.5.1 succinate + 2,6-dichlorophenolindophenol
-
Mycolicibacterium smegmatis fumarate + reduced 2,6-dichlorophenolindophenol
-
ir
1.3.5.1 succinate + 2,6-dichlorophenolindophenol
-
Mycolicibacterium smegmatis ATCC 700084 fumarate + reduced 2,6-dichlorophenolindophenol
-
ir

Synonyms

EC Number Synonyms Comment Organism
1.3.5.1 MSMEG_0416
-
Mycolicibacterium smegmatis
1.3.5.1 MSMEG_0417
-
Mycolicibacterium smegmatis
1.3.5.1 MSMEG_0418
-
Mycolicibacterium smegmatis
1.3.5.1 MSMEG_0419
-
Mycolicibacterium smegmatis
1.3.5.1 MSMEG_0420
-
Mycolicibacterium smegmatis
1.3.5.1 MSMEG_1669
-
Mycolicibacterium smegmatis
1.3.5.1 MSMEG_1670
-
Mycolicibacterium smegmatis
1.3.5.1 MSMEG_1671
-
Mycolicibacterium smegmatis
1.3.5.1 MSMEG_1672
-
Mycolicibacterium smegmatis
1.3.5.1 SDH1
-
Mycolicibacterium smegmatis
1.3.5.1 SDH2
-
Mycolicibacterium smegmatis

General Information

EC Number General Information Comment Organism
1.3.5.1 physiological function deletion of the sdh1 operon does not yield any growth phenotypes on succinate or other nonfermentable carbon sources Mycolicibacterium smegmatis
1.3.5.1 physiological function presence of the Sdh2 operon is essential for growth. Isoform Sdh2 is the generator of the membrane potential under hypoxia Mycolicibacterium smegmatis