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Literature summary extracted from

  • Katane, M.; Yamada, S.; Kawaguchi, G.; Chinen, M.; Matsumura, M.; Ando, T.; Doi, I.; Nakayama, K.; Kaneko, Y.; Matsuda, S.; Saitoh, Y.; Miyamoto, T.; Sekine, M.; Yamaotsu, N.; Hirono, S.; Homma, H.
    Identification of novel D-aspartate oxidase inhibitors by in silico screening and their functional and structural characterization in vitro (2015), J. Med. Chem., 58, 7328-7340 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.4.3.1 expressed in Escherichia coli L21(DE3)pLysS cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.1 1-hydroxy-1H-indole-2-carboxylic acid
-
 Homo sapiens
1.4.3.1 2-amino-5-chlorobenzoic acid
-
 Homo sapiens
1.4.3.1 2-amino-5-methylthiophene-3-carboxylic acid
-
 Homo sapiens
1.4.3.1 2-aminopyridine-3-carboxylic acid
-
 Homo sapiens
1.4.3.1 2-aminopyridine-4-carboxylic acid
-
 Homo sapiens
1.4.3.1 2-hydroxy-6-methylpyridine-3-carboxylic acid
-
 Homo sapiens
1.4.3.1 3-aminobenzoic acid
-
 Homo sapiens
1.4.3.1 3-aminopyridine-2-carboxylic acid
-
 Homo sapiens
1.4.3.1 3-aminopyridine-4-carboxylic acid
-
 Homo sapiens
1.4.3.1 3-hydroxypyridine-2-carboxylic acid
-
 Homo sapiens
1.4.3.1 4-aminopyridine-2-carboxylic acid
-
 Homo sapiens
1.4.3.1 4-aminopyridine-3-carboxylic acid
-
 Homo sapiens
1.4.3.1 4-carbamoylthiophene-2-carboxylic acid
-
 Homo sapiens
1.4.3.1 5-(dimethylamino)pyridine-3-carboxylic acid
-
 Homo sapiens
1.4.3.1 5-(methylamino)pyridine-3-carboxylic acid
-
 Homo sapiens
1.4.3.1 5-(trifluoromethyl)pyridine-3-carboxylic acid
-
 Homo sapiens
1.4.3.1 5-aminonicotinic acid
-
 Homo sapiens
1.4.3.1 5-aminopyridine-2-carboxylic acid
-
 Homo sapiens
1.4.3.1 5-bromopyridine-3-carboxylic acid
-
 Homo sapiens
1.4.3.1 5-chloro-2-hydroxybenzoic acid
-
 Homo sapiens
1.4.3.1 5-chloropyridine-3-carboxylic acid
-
 Homo sapiens
1.4.3.1 5-fluoro-2-hydroxybenzoic acid
-
 Homo sapiens
1.4.3.1 5-fluoropyridine-3-carboxylic acid
-
 Homo sapiens
1.4.3.1 5-hydroxypyridine-3-carboxylic acid
-
 Homo sapiens
1.4.3.1 5-methoxypyridine-3-carboxylic acid
-
 Homo sapiens
1.4.3.1 5-methylpyridine-3-carboxylic acid
-
 Homo sapiens
1.4.3.1 5-nitropyridine-3-carboxylic acid
-
 Homo sapiens
1.4.3.1 5-phenylpyridine-3-carboxylic acid
-
 Homo sapiens
1.4.3.1 5-sulfopyridine-3-carboxylic acid
-
 Homo sapiens
1.4.3.1 6-aminopyridine-2-carboxylic acid
-
 Homo sapiens
1.4.3.1 6-aminopyridine-3-carboxylic acid
-
 Homo sapiens
1.4.3.1 7-hydroxy-4-hydro-1,2,4-triazolo[4,3-a]pyrimidine-6-carboxylic acid
-
 Homo sapiens
1.4.3.1 benzoic acid
-
 Homo sapiens
1.4.3.1 malonic acid
-
 Homo sapiens
1.4.3.1 pyridin-3-amine
-
 Homo sapiens
1.4.3.1 pyridine-3,5-dicarboxylic acid
-
 Homo sapiens
1.4.3.1 pyridine-3-carboxylic acid
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.3.1 D-aspartate + H2O + O2 Homo sapiens
-
 oxaloacetate + NH3 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.1 Homo sapiens Q99489
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.1 D-aspartate + H2O + O2
-
 Homo sapiens oxaloacetate + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.1 DASPO
-
 Homo sapiens
1.4.3.1 DDO
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.4.3.1 0.0038
-
 5-aminonicotinic acid at pH 8.3 and 37°C Homo sapiens
1.4.3.1 0.0151
-
 7-hydroxy-4-hydro-1,2,4-triazolo[4,3-a]pyrimidine-6-carboxylic acid at pH 8.3 and 37°C Homo sapiens
1.4.3.1 0.153
-
 malonic acid at pH 8.3 and 37°C Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.4.3.1 0.0219
-
 at pH 8.3 and 37°C Homo sapiens 5-aminonicotinic acid
1.4.3.1 0.1
-
 IC50 above 0.1 mM, at pH 8.3 and 37°C Homo sapiens 4-aminopyridine-3-carboxylic acid
1.4.3.1 0.1
-
 IC50 above 0.1 mM, at pH 8.3 and 37°C Homo sapiens 2-aminopyridine-4-carboxylic acid
1.4.3.1 0.1
-
 IC50 above 0.1 mM, at pH 8.3 and 37°C Homo sapiens 6-aminopyridine-2-carboxylic acid
1.4.3.1 0.1
-
 IC50 above 0.1 mM, at pH 8.3 and 37°C Homo sapiens 4-aminopyridine-2-carboxylic acid
1.4.3.1 1
-
 IC50 above 1 mM, at pH 8.3 and 37°C Homo sapiens 1-hydroxy-1H-indole-2-carboxylic acid
1.4.3.1 1
-
 IC50 above 1 mM, at pH 8.3 and 37°C Homo sapiens 3-aminopyridine-2-carboxylic acid
1.4.3.1 1
-
 IC50 above 1 mM, at pH 8.3 and 37°C Homo sapiens 2-aminopyridine-3-carboxylic acid
1.4.3.1 1
-
 IC50 above 1 mM, at pH 8.3 and 37°C Homo sapiens 5-(dimethylamino)pyridine-3-carboxylic acid
1.4.3.1 2.364
-
 at pH 8.3 and 37°C Homo sapiens 6-aminopyridine-3-carboxylic acid
1.4.3.1 2.778
-
 at pH 8.3 and 37°C Homo sapiens pyridine-3-carboxylic acid
1.4.3.1 3.351
-
 at pH 8.3 and 37°C Homo sapiens 5-hydroxypyridine-3-carboxylic acid
1.4.3.1 3.541
-
 at pH 8.3 and 37°C Homo sapiens 5-(methylamino)pyridine-3-carboxylic acid
1.4.3.1 5
-
 IC50 above 5 mM, at pH 8.3 and 37°C Homo sapiens 4-carbamoylthiophene-2-carboxylic acid
1.4.3.1 5
-
 IC50 above 5 mM, at pH 8.3 and 37°C Homo sapiens 3-aminopyridine-4-carboxylic acid
1.4.3.1 5
-
 IC50 above 5 mM, at pH 8.3 and 37°C Homo sapiens 5-phenylpyridine-3-carboxylic acid
1.4.3.1 5.472
-
 at pH 8.3 and 37°C Homo sapiens 5-methylpyridine-3-carboxylic acid
1.4.3.1 10
-
 IC50 above 10 mM, at pH 8.3 and 37°C Homo sapiens 3-aminobenzoic acid
1.4.3.1 10
-
 IC50 above 10 mM, at pH 8.3 and 37°C Homo sapiens pyridine-3,5-dicarboxylic acid
1.4.3.1 10
-
 IC50 above 10 mM, at pH 8.3 and 37°C Homo sapiens 5-fluoro-2-hydroxybenzoic acid
1.4.3.1 10
-
 IC50 above 10 mM, at pH 8.3 and 37°C Homo sapiens 3-hydroxypyridine-2-carboxylic acid
1.4.3.1 10
-
 IC50 above 10 mM, at pH 8.3 and 37°C Homo sapiens 2-amino-5-chlorobenzoic acid
1.4.3.1 10
-
 IC50 above 10 mM, at pH 8.3 and 37°C Homo sapiens 5-chloro-2-hydroxybenzoic acid
1.4.3.1 10
-
 IC50 above 10 mM, at pH 8.3 and 37°C Homo sapiens 2-hydroxy-6-methylpyridine-3-carboxylic acid
1.4.3.1 10
-
 IC50 above 10 mM, at pH 8.3 and 37°C Homo sapiens pyridin-3-amine
1.4.3.1 10
-
 IC50 above 10 mM, at pH 8.3 and 37°C Homo sapiens 5-aminopyridine-2-carboxylic acid
1.4.3.1 10
-
 IC50 above 10 mM, at pH 8.3 and 37°C Homo sapiens 5-methoxypyridine-3-carboxylic acid
1.4.3.1 10
-
 IC50 above 10 mM, at pH 8.3 and 37°C Homo sapiens 5-fluoropyridine-3-carboxylic acid
1.4.3.1 10
-
 IC50 above 10 mM, at pH 8.3 and 37°C Homo sapiens 5-chloropyridine-3-carboxylic acid
1.4.3.1 10
-
 IC50 above 10 mM, at pH 8.3 and 37°C Homo sapiens 5-bromopyridine-3-carboxylic acid
1.4.3.1 10
-
 IC50 above 10 mM, at pH 8.3 and 37°C Homo sapiens 5-nitropyridine-3-carboxylic acid
1.4.3.1 10
-
 IC50 above 10 mM, at pH 8.3 and 37°C Homo sapiens 5-(trifluoromethyl)pyridine-3-carboxylic acid
1.4.3.1 10
-
 IC50 above 10 mM, at pH 8.3 and 37°C Homo sapiens 5-sulfopyridine-3-carboxylic acid