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Literature summary extracted from

  • Nasiri, H.R.; Madej, M.G.; Panisch, R.; Lafontaine, M.; Bats, J.W.; Lancaster, C.R.; Schwalbe, H.
    Design, synthesis, and biological testing of novel naphthoquinones as substrate-based inhibitors of the quinol/fumarate reductase from Wolinella succinogenes (2013), J. Med. Chem., 56, 9530-9541 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.5.1 2-bromo-3-ethyl-1,4-naphthoquinone
-
 Wolinella succinogenes
1.3.5.1 2-bromo-3-methyl-1,4-naphthoquinone
-
 Wolinella succinogenes

Organism

EC Number Organism UniProt Comment Textmining
1.3.5.1 Wolinella succinogenes P17412 and P17596 and P17413 P17412 i.e. subunit FrdA, P17596 i.e. subunit FrdB, P17413 i.e. subunit FrdC
-
1.3.5.1 Wolinella succinogenes DSM 1740 P17412 and P17596 and P17413 P17412 i.e. subunit FrdA, P17596 i.e. subunit FrdB, P17413 i.e. subunit FrdC
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.5.1 fumarate + a quinol
-
 Wolinella succinogenes succinate + a quinone
-
 r
1.3.5.1 fumarate + a quinol
-
 Wolinella succinogenes DSM 1740 succinate + a quinone
-
 r
1.3.5.1 succinate + a quinone
-
 Wolinella succinogenes fumarate + a quinol
-
 r
1.3.5.1 succinate + a quinone
-
 Wolinella succinogenes DSM 1740 fumarate + a quinol
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.3.5.1 FrdA
-
 Wolinella succinogenes
1.3.5.1 FrdC
-
 Wolinella succinogenes

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.3.5.1 0.000061
-
 inhibition of quinol oxidation by fumarate, pH 7.4, 37°C Wolinella succinogenes 2-bromo-3-methyl-1,4-naphthoquinone
1.3.5.1 0.0006
-
 inhibition of quinone reduction by succinate, pH 7.4, 37°C Wolinella succinogenes 2-bromo-3-ethyl-1,4-naphthoquinone
1.3.5.1 0.00061
-
 inhibition of quinol oxidation by fumarate, pH 7.4, 37°C Wolinella succinogenes 2-bromo-3-ethyl-1,4-naphthoquinone
1.3.5.1 0.00109
-
 inhibition of quinone reduction by succinate, pH 7.4, 37°C Wolinella succinogenes 2-bromo-3-methyl-1,4-naphthoquinone