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Literature summary extracted from

  • Hopkins, S.C.; Heffernan, M.L.; Saraswat, L.D.; Bowen, C.A.; Melnick, L.; Hardy, L.W.; Orsini, M.A.; Allen, M.S.; Koch, P.; Spear, K.L.; Foglesong, R.J.; Soukri, M.; Chytil, M.; Fang, Q.K.; Jones, S.W.; Varney, M.A.; Panatier, A.; Oliet, S.H.; Pollegioni, L.; Piubelli, L.; Molla, G.; Nardini, M.; Large, T.H.
    Structural, kinetic, and pharmacodynamic mechanisms of D-amino acid oxidase inhibition by small molecules (2013), J. Med. Chem., 56, 3710-3724 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.4.3.3 expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.4.3.3
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.3 3-(2-phenylethyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
 Homo sapiens
1.4.3.3 3-hydroxy-2H-1-benzopyran-2-one
-
 Homo sapiens
1.4.3.3 4-[2-(4-chlorophenyl)ethyl]-1H-pyrrole-2-carboxylic acid
-
 Homo sapiens
1.4.3.3 4H-thieno[3,2-b]pyrrole-5-carboxylic acid
-
 Homo sapiens
1.4.3.3 5,6-dichloro-1,2-benzoxazol-3-ol
-
 Homo sapiens
1.4.3.3 benzoate
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.3 Homo sapiens P14920
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.4.3.3 Ni-NTA column chromatography and gel filtration Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.3 D-Ser + H2O + O2
-
 Homo sapiens 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.3 DAAO
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.3 FAD
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.4.3.3 0.0000017
-
 5,6-dichloro-1,2-benzoxazol-3-ol pH and temperature not specified in the publication Homo sapiens
1.4.3.3 0.0000035
-
 4H-thieno[3,2-b]pyrrole-5-carboxylic acid pH and temperature not specified in the publication Homo sapiens
1.4.3.3 0.0000072
-
 4-[2-(4-chlorophenyl)ethyl]-1H-pyrrole-2-carboxylic acid pH and temperature not specified in the publication Homo sapiens
1.4.3.3 0.000013
-
 3-hydroxy-2H-1-benzopyran-2-one pH and temperature not specified in the publication Homo sapiens
1.4.3.3 0.00019
-
 3-(2-phenylethyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid pH and temperature not specified in the publication Homo sapiens
1.4.3.3 0.002
-
 benzoate pH and temperature not specified in the publication Homo sapiens