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Literature summary extracted from

  • Unissa, A.N.; Doss C, G.P.; Kumar, T.; Swathi, S.; Lakshmi, A.R.; Hanna, L.E.
    Analysis of interactions of clinical mutants of catalase-peroxidase (KatG) responsible for isoniazid resistance in Mycobacterium tuberculosis with derivatives of isoniazid (2017), J. Glob. Antimicrob. Resist., 11, 57-67 .
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.11.1.21 S315G the mutation leads to isoniazid resistance Mycobacterium tuberculosis
1.11.1.21 S315I the mutation leads to isoniazid resistance Mycobacterium tuberculosis
1.11.1.21 S315N the mutation leads to isoniazid resistance Mycobacterium tuberculosis
1.11.1.21 S315R the mutation leads to isoniazid resistance Mycobacterium tuberculosis
1.11.1.21 S315T the mutation leads to isoniazid resistance Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.11.1.21 2 H2O2 Mycobacterium tuberculosis
-
 O2 + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.21 Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.21 2 H2O2
-
 Mycobacterium tuberculosis O2 + H2O
-
 ?
1.11.1.21 isoniazid + H2O2
-
 Mycobacterium tuberculosis ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.11.1.21 KatG
-
 Mycobacterium tuberculosis