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Literature summary extracted from

  • Pinske, C.; Jaroschinsky, M.; Linek, S.; Kelly, C.L.; Sargent, F.; Sawers, R.G.
    Physiology and bioenergetics of [NiFe]-hydrogenase 2-catalyzed H2-consuming and H2-producing reactions in Escherichia coli (2015), J. Bacteriol., 197, 296-306 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.12.99.6 demethylmenaquinone
-
 Escherichia coli
1.12.99.6 menaquinone
-
 Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.12.99.6 Carbonyl cyanide m-chlorophenylhydrazone
-
 Escherichia coli

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.12.99.6 membrane
-
 Escherichia coli 16020
-

Organism

EC Number Organism UniProt Comment Textmining
1.12.99.6 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.12.99.6 H2 + 2,3,5-triphenyltetrazolium chloride
-
 Escherichia coli reduced 2,3,5-triphenyltetrazolium chloride
-
 ?
1.12.99.6 H2 + benzyl viologen
-
 Escherichia coli reduced benzyl viologen
-
 ?
1.12.99.6 H2 + fumarate
-
 Escherichia coli succinate
-
 ?
1.12.99.6 additional information the enzyme exhibits both proton-reducing and H2-oxidizing activities Escherichia coli ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.12.99.6 heterotetramer
-
 Escherichia coli

Synonyms

EC Number Synonyms Comment Organism
1.12.99.6 HybA subunit Escherichia coli
1.12.99.6 Hyd-2
-
 Escherichia coli
1.12.99.6 hydrogenase 2
-
 Escherichia coli
1.12.99.6 [NiFe]-hydrogenase 2
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.12.99.6 iron-sulfur center
-
 Escherichia coli

Expression

EC Number Organism Comment Expression
1.12.99.6 Escherichia coli enzyme synthesis is strongly upregulated during growth on glycerol or on glycerol-fumarate up