Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Wojcik, A.; Broclawik, E.; Siegbahn, P.E.; Lundberg, M.; Moran, G.; Borowski, T.
    Role of substrate positioning in the catalytic reaction of 4-hydroxyphenylpyruvate dioxygenase - a QM/MM study (2014), J. Am. Chem. Soc., 136, 14472-14485 .
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.13.11.27 crystal structure analysis of HPPD-Fe(II)-acetate complex, PDB ID 1CJX Pseudomonas fluorescens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.13.11.27 Fe Fe(II), Fe(III), and Fe(IV) during oxygenation and hydroxylation, overview. The iron ion is coordinated by a His-His-Glu triad, structure of HPPD-Fe(II)-acetate complex, overview Pseudomonas fluorescens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.27 4-hydroxyphenylpyruvate + O2 Pseudomonas fluorescens
-
 homogentisate + CO2
-
 ?
1.13.11.27 4-hydroxyphenylpyruvate + O2 Pseudomonas fluorescens ATCC 13525
-
 homogentisate + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.27 Pseudomonas fluorescens
-
-
-
1.13.11.27 Pseudomonas fluorescens ATCC 13525
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.13.11.27 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2 reaction mechanism, quantum mechanics/molecular mechanics calculations and simulations, detailed overview Pseudomonas fluorescens
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.27 4-hydroxyphenylpyruvate + O2
-
 Pseudomonas fluorescens homogentisate + CO2
-
 ?
1.13.11.27 4-hydroxyphenylpyruvate + O2
-
 Pseudomonas fluorescens ATCC 13525 homogentisate + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
1.13.11.27 More enzyme structure comparisons, structure homology modeling, overview Pseudomonas fluorescens

Synonyms

EC Number Synonyms Comment Organism
1.13.11.27 HPPD
-
 Pseudomonas fluorescens

General Information

EC Number General Information Comment Organism
1.13.11.27 metabolism suggested hydroxylation mechanisms for HMS and HPPD and pathways leading to alternative products: oxepinone and quinolacetate Pseudomonas fluorescens
1.13.11.27 additional information molecular dynamics simulations are performed for the HPPD-Fe(IV)=O-hydroxyphenylacetate complex in order to obtain a reliable starting structure for quantum mechanics/molecular mechanics calculations of ring hydroxylation and coupled rearrangement reactions catalyzed by the enzyme HPPD, structure of HPPD-Fe(II)-acetate complex, structure homology modeling, overview Pseudomonas fluorescens