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Literature summary extracted from

  • Gonyar, L.A.; Fankhauser, S.C.; Goldberg, J.B.
    Single amino acid substitution in homogentisate 1,2-dioxygenase is responsible for pigmentation in a subset of Burkholderia cepacia complex isolates (2015), Environ. Microbiol. Rep., 7, 180-187 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.5 expressed in Burkholderia cepacia strain J2315 Burkholderia cepacia

Protein Variants

EC Number Protein Variants Comment Organism
1.13.11.5 R378G the mutation is associated with the loss of pigmentation Burkholderia cepacia

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.5 homogentisate + O2 Burkholderia cepacia
-
 4-maleylacetoacetate
-
 ?
1.13.11.5 homogentisate + O2 Burkholderia cepacia K56-2
-
 4-maleylacetoacetate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.5 Burkholderia cepacia
-
-
-
1.13.11.5 Burkholderia cepacia K56-2
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.5 homogentisate + O2
-
 Burkholderia cepacia 4-maleylacetoacetate
-
 ?
1.13.11.5 homogentisate + O2
-
 Burkholderia cepacia K56-2 4-maleylacetoacetate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.5 HmgA
-
 Burkholderia cepacia

General Information

EC Number General Information Comment Organism
1.13.11.5 physiological function homogentisate 1,2-dioxygenase is a potentially critical enzyme for regulation of pigment production Burkholderia cepacia