EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.4.3.4 | 3-(4-fluorophenyl)-5-(2-naphthyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
1.4.3.4 | 3-(4-fluorophenyl)-5-(4-acetylaminophenyl)-N-phenyl-4,5-dihydro-1H -pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
1.4.3.4 | 3-(4-fluorophenyl)-5-(4-acetylaminophenyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
1.4.3.4 | 3-(4-fluorophenyl)-5-(4-methoxyphenyl)-N-methyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
1.4.3.4 | 3-(4-fluorophenyl)-5-(4-methoxyphenyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
1.4.3.4 | 3-(4-fluorophenyl)-5-(4-methylphenyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
1.4.3.4 | 3-(4-fluorophenyl)-N,5-diphenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
1.4.3.4 | 3-(4-fluorophenyl)-N-methyl-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
1.4.3.4 | 3-(4-fluorophenyl)-N-methyl-5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
1.4.3.4 | 3-(4-fluorophenyl)-N-methyl-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
1.4.3.4 | 4-[1-(cyclopropylcarbamothioyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-5-yl]-N-methylbenzamide | - |
Rattus norvegicus | |
1.4.3.4 | 4-[1-(ethylcarbamothioyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-5-yl]-N-methylbenzamide | - |
Rattus norvegicus | |
1.4.3.4 | 4-[3-(4-fluorophenyl)-1-(methylcarbamothioyl)-4,5-dihydro-1H-pyrazol-5-yl]-N-methylbenzamide | - |
Rattus norvegicus | |
1.4.3.4 | 5-(4-bromophenyl)-3-(4-fluorophenyl)-N-methyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
1.4.3.4 | 5-(4-bromophenyl)-3-(4-fluorophenyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
1.4.3.4 | 5-(4-bromophenyl)-N-cyclopropyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
1.4.3.4 | 5-(4-bromophenyl)-N-ethyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
1.4.3.4 | 5-(4-chlorophenyl)-3-(4-fluorophenyl)-N-methyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
1.4.3.4 | 5-(4-chlorophenyl)-3-(4-fluorophenyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
1.4.3.4 | 5-(4-chlorophenyl)-N-cyclopropyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
1.4.3.4 | 5-(4-chlorophenyl)-N-ethyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
1.4.3.4 | Clorgyline | - |
Rattus norvegicus | |
1.4.3.4 | N-cyclopropyl-3-(4-fluorophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
1.4.3.4 | N-cyclopropyl-3-(4-fluorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
1.4.3.4 | N-cyclopropyl-3-(4-fluorophenyl)-5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
1.4.3.4 | N-cyclopropyl-3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
1.4.3.4 | N-ethyl-3-(4-fluorophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
1.4.3.4 | N-ethyl-3-(4-fluorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
1.4.3.4 | N-ethyl-3-(4-fluorophenyl)-5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
1.4.3.4 | N-ethyl-3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
1.4.3.4 | Pargyline | - |
Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.4.3.4 | mitochondrion | - |
Rattus norvegicus | 5739 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.4.3.4 | Rattus norvegicus | P19643 | - |
- |
1.4.3.4 | Rattus norvegicus | P21396 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.4.3.4 | - |
Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.4.3.4 | liver | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.4.3.4 | 4-tyramine + H2O + O2 | - |
Rattus norvegicus | (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2 | - |
? | |
1.4.3.4 | benzylamine + H2O + O2 | - |
Rattus norvegicus | benzaldehyde + NH3 + H2O2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.4.3.4 | MAO-A | - |
Rattus norvegicus |
1.4.3.4 | MAO-B | - |
Rattus norvegicus |
1.4.3.4 | monoamine oxidase A | - |
Rattus norvegicus |
1.4.3.4 | monoamine oxidase B | - |
Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.4.3.4 | FAD | - |
Rattus norvegicus |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.4.3.4 | 0.00172 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | Clorgyline | |
1.4.3.4 | 0.00625 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | 5-(4-chlorophenyl)-3-(4-fluorophenyl)-N-methyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.00834 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | 5-(4-chlorophenyl)-N-ethyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.01339 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | 5-(4-bromophenyl)-3-(4-fluorophenyl)-N-methyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.0199 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | 5-(4-chlorophenyl)-N-cyclopropyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.0299 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | 5-(4-bromophenyl)-N-ethyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.03044 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | 5-(4-bromophenyl)-N-cyclopropyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.03724 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | 5-(4-chlorophenyl)-3-(4-fluorophenyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.05522 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | 3-(4-fluorophenyl)-5-(4-methoxyphenyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.06128 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | 3-(4-fluorophenyl)-N-methyl-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.08991 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | N-cyclopropyl-3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.09045 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | 3-(4-fluorophenyl)-N-methyl-5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.09053 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | N-ethyl-3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.09821 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | N-ethyl-3-(4-fluorophenyl)-5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.09856 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | 3-(4-fluorophenyl)-5-(2-naphthyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.0999 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | N-cyclopropyl-3-(4-fluorophenyl)-5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.10077 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | 4-[3-(4-fluorophenyl)-1-(methylcarbamothioyl)-4,5-dihydro-1H-pyrazol-5-yl]-N-methylbenzamide | |
1.4.3.4 | 0.1842 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | N-ethyl-3-(4-fluorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.1859 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | N-ethyl-3-(4-fluorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.19356 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | 3-(4-fluorophenyl)-5-(4-methoxyphenyl)-N-methyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.19723 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | N-ethyl-3-(4-fluorophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.19844 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | 3-(4-fluorophenyl)-N-methyl-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.19886 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | N-ethyl-3-(4-fluorophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.20534 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | 3-(4-fluorophenyl)-N-methyl-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.2459 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | N-cyclopropyl-3-(4-fluorophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.25623 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | 3-(4-fluorophenyl)-5-(4-methoxyphenyl)-N-methyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.26476 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | N-cyclopropyl-3-(4-fluorophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.39 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | Pargyline | |
1.4.3.4 | 0.43089 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | N-cyclopropyl-3-(4-fluorophenyl)-5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.47004 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | N-ethyl-3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.47019 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | 3-(4-fluorophenyl)-N-methyl-5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.47021 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | 3-(4-fluorophenyl)-N-methyl-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.47022 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | 5-(4-chlorophenyl)-N-ethyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.47045 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | 4-[3-(4-fluorophenyl)-1-(methylcarbamothioyl)-4,5-dihydro-1H-pyrazol-5-yl]-N-methylbenzamide | |
1.4.3.4 | 0.47066 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | N-ethyl-3-(4-fluorophenyl)-5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.47067 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | 5-(4-bromophenyl)-N-cyclopropyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.48023 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | 5-(4-bromophenyl)-N-ethyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.48055 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | N-cyclopropyl-3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.4874 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | 3-(4-fluorophenyl)-5-(2-naphthyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.48882 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | 5-(4-chlorophenyl)-3-(4-fluorophenyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.49622 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | 5-(4-bromophenyl)-3-(4-fluorophenyl)-N-methyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.50011 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | 5-(4-chlorophenyl)-N-cyclopropyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.50023 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | 5-(4-chlorophenyl)-3-(4-fluorophenyl)-N-methyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
1.4.3.4 | 0.50045 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | 3-(4-fluorophenyl)-5-(4-methoxyphenyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide |