EC Number | Application | Comment | Organism |
---|---|---|---|
1.14.13.9 | pharmacology | kynurenine represents a branch point of the kynurenine pathway, being converted into the neurotoxin 3-hydroxykynurenine via kynurenine monooxygenase, neuroprotectant kynurenic acid, and anthranilic acid. As a result of this branch point, kynurenine monooxygenase is an attractive drug target for several neurodegenerative and/or neuroinflammatory diseases, especially Huntington's, Alzheimer's, and Parkinson's diseases | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.13.9 | Ro 61-8048 | - |
Pseudomonas fluorescens | |
1.14.13.9 | Ro 61-8048 | - |
Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.14.13.9 | mitochondrial membrane | the C terminus of the enzyme contains a putative outer mitochondrial membrane-targeting sequence and this portion of the molecule is required enzyme function | Sus scrofa | 31966 | - |
1.14.13.9 | mitochondrial membrane | the C terminus of the enzyme contains a putative outer mitochondrial membrane-targeting sequence and this portion of the molecule is required enzyme function | Homo sapiens | 31966 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.13.9 | Homo sapiens | O15229 | - |
- |
1.14.13.9 | Pseudomonas fluorescens | Q84HF5 | - |
- |
1.14.13.9 | Rattus norvegicus | O88867 | - |
- |
1.14.13.9 | Sus scrofa | Q9MZS9 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.13.9 | brain | - |
Rattus norvegicus | - |
1.14.13.9 | CHO cell | - |
Homo sapiens | - |
1.14.13.9 | kidney | - |
Rattus norvegicus | - |
1.14.13.9 | liver | - |
Homo sapiens | - |
1.14.13.9 | liver | - |
Rattus norvegicus | - |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.14.13.9 | FAD | flavoenzyme | Sus scrofa | |
1.14.13.9 | FAD | flavoenzyme | Pseudomonas fluorescens | |
1.14.13.9 | FAD | flavoenzyme | Homo sapiens | |
1.14.13.9 | FAD | flavoenzyme | Rattus norvegicus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.14.13.9 | drug target | kynurenine represents a branch point of the kynurenine pathway, being converted into the neurotoxin 3-hydroxykynurenine via kynurenine monooxygenase, neuroprotectant kynurenic acid, and anthranilic acid. As a result of this branch point, kynurenine monooxygenase is an attractive drug target for several neurodegenerative and/or neuroinflammatory diseases, especially Huntington's, Alzheimer's, and Parkinson's diseases | Homo sapiens |
1.14.13.9 | malfunction | human polymorphism in the C-terminal region of the enzyme results in an Arg452Cys mutation, statistically linked to bipolar disorder and schizophrenia | Homo sapiens |
1.14.13.9 | metabolism | enzyme of the kynurenine pathway, which is the major catabolic route of tryptophan | Homo sapiens |