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Literature summary extracted from

  • Smith, J.R.; Jamie, J.F.; Guillemin, G.J.
    Kynurenine-3-monooxygenase a review of structure, mechanism, and inhibitors (2016), Drug Discov. Today, 21, 315-324 .
    View publication on PubMed

Application

EC Number Application Comment Organism
1.14.13.9 pharmacology kynurenine represents a branch point of the kynurenine pathway, being converted into the neurotoxin 3-hydroxykynurenine via kynurenine monooxygenase, neuroprotectant kynurenic acid, and anthranilic acid. As a result of this branch point, kynurenine monooxygenase is an attractive drug target for several neurodegenerative and/or neuroinflammatory diseases, especially Huntington's, Alzheimer's, and Parkinson's diseases Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.13.9 Ro 61-8048
-
Pseudomonas fluorescens
1.14.13.9 Ro 61-8048
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.13.9 mitochondrial membrane the C terminus of the enzyme contains a putative outer mitochondrial membrane-targeting sequence and this portion of the molecule is required enzyme function Sus scrofa 31966
-
1.14.13.9 mitochondrial membrane the C terminus of the enzyme contains a putative outer mitochondrial membrane-targeting sequence and this portion of the molecule is required enzyme function Homo sapiens 31966
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.9 Homo sapiens O15229
-
-
1.14.13.9 Pseudomonas fluorescens Q84HF5
-
-
1.14.13.9 Rattus norvegicus O88867
-
-
1.14.13.9 Sus scrofa Q9MZS9
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.13.9 brain
-
Rattus norvegicus
-
1.14.13.9 CHO cell
-
Homo sapiens
-
1.14.13.9 kidney
-
Rattus norvegicus
-
1.14.13.9 liver
-
Homo sapiens
-
1.14.13.9 liver
-
Rattus norvegicus
-

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.9 FAD flavoenzyme Sus scrofa
1.14.13.9 FAD flavoenzyme Pseudomonas fluorescens
1.14.13.9 FAD flavoenzyme Homo sapiens
1.14.13.9 FAD flavoenzyme Rattus norvegicus

General Information

EC Number General Information Comment Organism
1.14.13.9 drug target kynurenine represents a branch point of the kynurenine pathway, being converted into the neurotoxin 3-hydroxykynurenine via kynurenine monooxygenase, neuroprotectant kynurenic acid, and anthranilic acid. As a result of this branch point, kynurenine monooxygenase is an attractive drug target for several neurodegenerative and/or neuroinflammatory diseases, especially Huntington's, Alzheimer's, and Parkinson's diseases Homo sapiens
1.14.13.9 malfunction human polymorphism in the C-terminal region of the enzyme results in an Arg452Cys mutation, statistically linked to bipolar disorder and schizophrenia Homo sapiens
1.14.13.9 metabolism enzyme of the kynurenine pathway, which is the major catabolic route of tryptophan Homo sapiens