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Literature summary extracted from

  • Mathew, B.; Mathew, G.E.; Ucar, G.; Baysal, I.; Suresh, J.; Vilapurathu, J.K.; Prakasan, A.; Suresh, J.K.; Thomas, A.
    Development of fluorinated methoxylated chalcones as selective monoamine oxidase-B inhibitors Synthesis, biochemistry and molecular docking studies (2015), Bioorg. Chem., 62, 22-29 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 (2E)-1-(4-methoxyphenyl)-3-[2-(trifluoromethyl)phenyl]prop-2-en-1-one competitive inhibition Homo sapiens
1.4.3.4 (2E)-1-(4-methoxyphenyl)-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-one competitive inhibition Homo sapiens
1.4.3.4 (2E)-3-(2-fluorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one competitive inhibition Homo sapiens
1.4.3.4 (2E)-3-(3-fluorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one competitive inhibition Homo sapiens
1.4.3.4 (2E)-3-(4-fluorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one competitive inhibition Homo sapiens
1.4.3.4 moclobemide
-
 Homo sapiens
1.4.3.4 selegiline
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Homo sapiens P27338
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 4-tyramine + H2O + O2
-
 Homo sapiens (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.4 MAO-B
-
 Homo sapiens
1.4.3.4 monoamine oxidase-B
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.4.3.4 0.00022
-
 (2E)-1-(4-methoxyphenyl)-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-one at pH 7.4 and 37°C Homo sapiens
1.4.3.4 0.00027
-
 (2E)-3-(4-fluorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one at pH 7.4 and 37°C Homo sapiens
1.4.3.4 0.00028
-
 (2E)-3-(2-fluorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one at pH 7.4 and 37°C Homo sapiens
1.4.3.4 0.00035
-
 selegiline at pH 7.4 and 37°C Homo sapiens
1.4.3.4 0.00035
-
 (2E)-3-(3-fluorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one at pH 7.4 and 37°C Homo sapiens
1.4.3.4 0.00036
-
 (2E)-1-(4-methoxyphenyl)-3-[2-(trifluoromethyl)phenyl]prop-2-en-1-one at pH 7.4 and 37°C Homo sapiens
1.4.3.4 0.00145
-
 moclobemide at pH 7.4 and 37°C Homo sapiens