EC Number | Cloned (Comment) | Organism |
---|---|---|
1.11.1.21 | expressed in Escherichia coli BL21(DE3) cells | Mycobacterium tuberculosis |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.11.1.21 | E291A | the mutant shows 89% peroxidase activity and 139% catalase activity compared to the wild type enzyme | Mycobacterium tuberculosis |
1.11.1.21 | E291K | the mutant shows 200% peroxidase activity and 79% catalase activity compared to the wild type enzyme | Mycobacterium tuberculosis |
1.11.1.21 | E291K/E292A | the mutant shows 222% peroxidase activity and 102% catalase activity compared to the wild type enzyme | Mycobacterium tuberculosis |
1.11.1.21 | I290A | the mutant shows 31% peroxidase activity and 93% catalase activity compared to the wild type enzyme | Mycobacterium tuberculosis |
1.11.1.21 | I290A/Q293A | the mutant shows 56% peroxidase activity and 64% catalase activity compared to the wild type enzyme | Mycobacterium tuberculosis |
1.11.1.21 | I290V | the mutant shows 35% peroxidase activity and 67% catalase activity compared to the wild type enzyme | Mycobacterium tuberculosis |
1.11.1.21 | I290V/Q293V | the mutant shows 44% peroxidase activity and 47% catalase activity compared to the wild type enzyme | Mycobacterium tuberculosis |
1.11.1.21 | Q293A | the mutant shows 59% peroxidase activity and 102% catalase activity compared to the wild type enzyme | Mycobacterium tuberculosis |
1.11.1.21 | Q293E | the mutant shows 62% peroxidase activity and 80% catalase activity compared to the wild type enzyme | Mycobacterium tuberculosis |
1.11.1.21 | Q293V | the mutant shows 25% peroxidase activity and 44% catalase activity compared to the wild type enzyme | Mycobacterium tuberculosis |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.11.1.21 | 0.023 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | mutant enzyme E291K, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 0.028 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | mutant enzyme E291K/E292A, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 0.037 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | mutant enzyme I290A/Q293A, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 0.05 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | mutant enzyme Q293E, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 0.06 | - |
H2O2 | mutant enzyme E291K, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 0.06 | - |
H2O2 | mutant enzyme E291K/E292A, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 0.07 | - |
H2O2 | mutant enzyme I290A/Q293A, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 0.071 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | mutant enzyme E291A, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 0.078 | - |
H2O2 | mutant enzyme Q293A, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 0.08 | - |
H2O2 | mutant enzyme I290V, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 0.08 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | mutant enzyme Q293A, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 0.081 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | mutant enzyme I290V/Q293V, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 0.087 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | wild type enzyme, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 0.089 | - |
H2O2 | mutant enzyme Q293E, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 0.09 | - |
H2O2 | mutant enzyme I290A, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 0.09 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | mutant enzyme Q293V, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 0.1 | - |
H2O2 | mutant enzyme E291A, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 0.13 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | mutant enzyme I290V, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 0.16 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | mutant enzyme I290A, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 0.21 | - |
H2O2 | mutant enzyme I290V/Q293V, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 0.31 | - |
H2O2 | wild type enzyme, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 0.5 | - |
H2O2 | mutant enzyme Q293V, at pH 5.0 and 23°C | Mycobacterium tuberculosis |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.11.1.21 | Mycobacterium tuberculosis | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.11.1.21 | Ni-NTA column chromatography | Mycobacterium tuberculosis |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.11.1.21 | 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O2 | - |
Mycobacterium tuberculosis | oxidized 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.11.1.21 | KatG | - |
Mycobacterium tuberculosis |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.11.1.21 | 13.3 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | mutant enzyme I290A/Q293A, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 13.6 | - |
H2O2 | mutant enzyme I290A/Q293A, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 15.2 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | mutant enzyme Q293V, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 20 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | mutant enzyme Q293E, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 22.5 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | mutant enzyme I290V/Q293V, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 23.8 | - |
H2O2 | mutant enzyme Q293E, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 24 | - |
H2O2 | mutant enzyme I290V/Q293V, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 26 | - |
H2O2 | mutant enzyme I290A, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 26 | - |
H2O2 | mutant enzyme I290V, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 26 | - |
H2O2 | mutant enzyme Q293V, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 27.8 | - |
H2O2 | mutant enzyme Q293A, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 28.5 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | mutant enzyme I290V, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 29.3 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | mutant enzyme Q293A, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 29.6 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | mutant enzyme E291K, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 32.5 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | mutant enzyme I290A, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 34 | - |
H2O2 | mutant enzyme E291K, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 35.3 | - |
H2O2 | mutant enzyme E291K/E292A, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 38 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | mutant enzyme E291K/E292A, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 39.7 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | mutant enzyme E291A, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 40 | - |
H2O2 | mutant enzyme E291A, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 55 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | wild type enzyme, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 83 | - |
H2O2 | wild type enzyme, at pH 5.0 and 23°C | Mycobacterium tuberculosis |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.11.1.21 | heme | - |
Mycobacterium tuberculosis |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.11.1.21 | 49 | - |
H2O2 | mutant enzyme Q293V, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 110 | - |
H2O2 | mutant enzyme I290V/Q293V, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 140 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | mutant enzyme E291K/E292A, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 160 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | mutant enzyme Q293V, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 200 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | mutant enzyme I290A, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 210 | - |
H2O2 | mutant enzyme I290A/Q293A, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 220 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | mutant enzyme I290V, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 268 | - |
H2O2 | mutant enzyme Q293E, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 270 | - |
H2O2 | wild type enzyme, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 280 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | mutant enzyme I290V/Q293V, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 310 | - |
H2O2 | mutant enzyme I290A, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 350 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | mutant enzyme I290A/Q293A, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 350 | - |
H2O2 | mutant enzyme I290V, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 370 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | mutant enzyme Q293A, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 380 | - |
H2O2 | mutant enzyme Q293A, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 390 | - |
H2O2 | mutant enzyme E291A, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 390 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | mutant enzyme Q293E, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 560 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | mutant enzyme E291A, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 600 | - |
H2O2 | mutant enzyme E291K, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 620 | - |
H2O2 | mutant enzyme E291K/E292A, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 630 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | wild type enzyme, at pH 5.0 and 23°C | Mycobacterium tuberculosis | |
1.11.1.21 | 1260 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | mutant enzyme E291K, at pH 5.0 and 23°C | Mycobacterium tuberculosis |