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Literature summary extracted from

  • Lee, J.J.; Kim, J.H.; Kim, D.G.; Kim, D.H.; Simborio, H.L.; Min, W.G.; Rhee, M.H.; Lim, J.H.; Chang, H.H.; Kim, S.
    Characterization of betaine aldehyde dehydrogenase (BetB) as an essential virulence factor of Brucella abortus (2014), Vet. Microbiol., 168, 131-140.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.8 betaine aldehyde + NAD+ + H2O Brucella abortus
-
 betaine + NADH + H+
-
 ?
1.2.1.8 betaine aldehyde + NAD+ + H2O Brucella abortus 9-941
-
 betaine + NADH + H+
-
 ?
1.2.1.8 betaine aldehyde + NADP+ + H2O Brucella abortus
-
 betaine + NADPH + H+
-
 ?
1.2.1.8 betaine aldehyde + NADP+ + H2O Brucella abortus 9-941
-
 betaine + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.8 Brucella abortus Q57EI0 544
-
1.2.1.8 Brucella abortus 9-941 Q57EI0 544
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.8 betaine aldehyde + NAD+ + H2O
-
 Brucella abortus betaine + NADH + H+
-
 ?
1.2.1.8 betaine aldehyde + NAD+ + H2O
-
 Brucella abortus 9-941 betaine + NADH + H+
-
 ?
1.2.1.8 betaine aldehyde + NADP+ + H2O
-
 Brucella abortus betaine + NADPH + H+
-
 ?
1.2.1.8 betaine aldehyde + NADP+ + H2O
-
 Brucella abortus 9-941 betaine + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.8 BetB
-
 Brucella abortus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.8 NAD+
-
 Brucella abortus
1.2.1.8 NADP+
-
 Brucella abortus

General Information

EC Number General Information Comment Organism
1.2.1.8 physiological function the betaine aldehyde dehydrogenase gene substantially affects the phagocytic pathway in human phagocytes and in host cells in mice. The enzyme is involved in the bacterial adherent ability to phagocytes and is responsible for the bacterial persistence and virulence in mice Brucella abortus