EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.153 | Drosophila melanogaster | - |
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EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.153 | sepiapterin reductase | - |
Drosophila melanogaster |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.1.1.153 | malfunction | tetrahydrobiopterin deficiencies are implicated in neuronal disorders. Drosophile melanogastersloss-of-function enzyme mutants are resonsibel for hyposensitivityy to oxidative stress, enzyme activity and tetrahydrobiopterin levels in the mutants are significantly reduced compared to wild-type, while levels of phosphorylated Akt and total Akt protein are increased in the enzyme mutants | Drosophila melanogaster |
1.1.1.153 | metabolism | sepiapterin reductase is a key enzyme in the biosynthesis of tetrahydrobiopterin (BH4), an essential cofactor for the synthesis of important biogenic amines, including catecholamines and serotonin | Drosophila melanogaster |
1.1.1.153 | physiological function | sepiapterin reductase plays an important role in the Akt pathway | Drosophila melanogaster |