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Literature summary extracted from

  • Nagel, J.; Culley, L.; Lu, Y.; Liu, E.; Matthews, P.; Stevens, J.; Page, J.
    EST analysis of hop glandular trichomes identifies an O-methyltransferase that catalyzes the biosynthesis of xanthohumol (2008), Plant Cell, 20, 186-200.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.338 desmethylxanthohumol competitive with respect to xanthohumol Humulus lupulus
2.1.1.338 S-adenosyl-L-homocysteine
-
Humulus lupulus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.338 0.018
-
desmethylxanthohumol pH 7.5, 30°C Humulus lupulus
2.1.1.338 0.286
-
S-adenosyl-L-methionine pH 7.5, 30°C Humulus lupulus
2.1.1.339 0.019
-
resveratrol pH 7.5, 30°C Humulus lupulus
2.1.1.339 0.023
-
desmethylxanthohumol pH 7.5, 30°C Humulus lupulus
2.1.1.339 0.031
-
xanthohumol pH 7.5, 30°C Humulus lupulus
2.1.1.339 0.034
-
S-adenosyl-L-methionine pH 7.5, 30°C Humulus lupulus
2.1.1.339 0.237
-
chalconaringenin pH 7.5, 30°C Humulus lupulus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.1.1.338 additional information bivalent cations (Mg2+, Fe2+, Zn2+, Cu2+, Ca2+, and Co2+) are not required for activity Humulus lupulus
2.1.1.339 additional information bivalent cations (Mg2+, Fe2+, Zn2+, Cu2+, Ca2+, and Co2+) are not required for activity Humulus lupulus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.338 39265
-
-
Humulus lupulus
2.1.1.338 76000
-
gel filtration Humulus lupulus
2.1.1.339 64000
-
gel filtration Humulus lupulus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.338 Humulus lupulus B0ZB55
-
-
2.1.1.339 Humulus lupulus B0ZB56
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.338 S-adenosyl-L-methionine + caffeic acid
-
Humulus lupulus S-adenosyl-L-homocysteine + ? 7% of the activity with desmethylxanthohumol ?
2.1.1.338 S-adenosyl-L-methionine + desmethylxanthohumol
-
Humulus lupulus S-adenosyl-L-homocysteine + xanthohumol
-
?
2.1.1.338 S-adenosyl-L-methionine + xanthogalenol 445% of the activity with desmethylxanthohumol Humulus lupulus S-adenosyl-L-homocysteine + ?
-
?
2.1.1.339 S-adenosyl-L-methionine + 2',4-dihydroxychalcone 45% of the activity with isoliquiritigenin Humulus lupulus S-adenosyl-L-homocysteine + ?
-
?
2.1.1.339 S-adenosyl-L-methionine + butein 50% of the activity with isoliquiritigenin Humulus lupulus S-adenosyl-L-homocysteine + ?
-
?
2.1.1.339 S-adenosyl-L-methionine + chalconaringenin 40% of the activity with isoliquiritigenin Humulus lupulus S-adenosyl-L-homocysteine + ?
-
?
2.1.1.339 S-adenosyl-L-methionine + desmethylxanthohumol 25% of the activity with isoliquiritigenin Humulus lupulus S-adenosyl-L-homocysteine + 4'-O-methyl-desmethylxanthohumol
-
?
2.1.1.339 S-adenosyl-L-methionine + guaiacol 42% of the activity with isoliquiritigenin Humulus lupulus S-adenosyl-L-homocysteine + ?
-
?
2.1.1.339 S-adenosyl-L-methionine + isoliquiritigenin
-
Humulus lupulus S-adenosyl-L-homocysteine + ?
-
?
2.1.1.339 S-adenosyl-L-methionine + resveratrol 87% of the activity with isoliquiritigenin Humulus lupulus S-adenosyl-L-homocysteine + ?
-
?
2.1.1.339 S-adenosyl-L-methionine + xanthohumol 36% of the activity with isoliquiritigenin Humulus lupulus S-adenosyl-L-homocysteine + 4'-O-methylxanthohumol
-
?

Subunits

EC Number Subunits Comment Organism
2.1.1.338 dimer 2 * 39265, calculated Humulus lupulus
2.1.1.339 dimer 2 * 39792, calculated Humulus lupulus

Synonyms

EC Number Synonyms Comment Organism
2.1.1.338 OMT1
-
Humulus lupulus
2.1.1.338 S-adenosyl-L-methionine-dependent O-methyltransferase
-
Humulus lupulus
2.1.1.339 OMT2
-
Humulus lupulus
2.1.1.339 S-adenosyl-L-methionine-dependent O-methyltransferase
-
Humulus lupulus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.1.1.338 30 37
-
Humulus lupulus
2.1.1.339 39
-
-
Humulus lupulus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.338 9
-
-
Humulus lupulus
2.1.1.339 8.5
-
-
Humulus lupulus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.338 0.002
-
desmethylxanthohumol pH 7.5, 30°C Humulus lupulus
2.1.1.338 0.098
-
S-adenosyl-L-homocysteine pH 7.5, 30°C Humulus lupulus

General Information

EC Number General Information Comment Organism
2.1.1.338 physiological function OMT1 performs the final reaction in xanthohumol biosynthesis by methylating desmethylxanthohumol to form xanthohumol Humulus lupulus