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Literature summary extracted from

  • Carmena, M.; Lombardia, M.O.; Ogawa, H.; Earnshaw, W.C.
    Polo kinase regulates the localization and activity of the chromosomal passenger complex in meiosis and mitosis in Drosophila melanogaster (2014), Open Biology, 4, 140162.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.21 Drosophila melanogaster P52304
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.21 larva
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 Drosophila melanogaster
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2.7.11.21 neuroblast
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 Drosophila melanogaster
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2.7.11.21 spermatocyte
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 Drosophila melanogaster
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General Information

EC Number General Information Comment Organism
2.7.11.21 malfunction phenotype of different polo allele combinations compared to the effect of chemical inhibition. The chromosomal passenger complex is mislocalized in polo mutant meiosis. This defective CPC localization is independent of the degree of disruption of the spindle midzone, as visualized by staining for microtubules Drosophila melanogaster
2.7.11.21 physiological function polo kinase regulates the localization and activity of the chromosomal passenger complex in meiosis and mitosis, e.g. in larval neuroblast mitoses, significant differences in the localization and activity of the chromosomal passenger complex in diploid tissues. Polo kinase is required for the correct localization and activity of the CPC at all stages of male meiosis as well as in larval neuroblast mitoses Drosophila melanogaster