EC Number | Cloned (Comment) | Organism |
---|---|---|
1.1.1.51 | gene AKR1C35, cloned from liver, DNA and amino acid sequence determination and analysis, sequence comparisons, recombinant expression of His-tagged wild-type and mutant enzymes in Escherichia coli strain BL21(DE3)pLysS | Mesocricetus auratus |
1.1.1.218 | gene AKR1C34, cloned from liver, DNA and amino acid sequence determination and analysis, sequence comparisons, recombinant expression of His-tagged enzyme in Escherichia coli strain BL21(DE3)pLysS | Mesocricetus auratus |
1.1.1.239 | gene AKR1C35, cloned from liver, DNA and amino acid sequence determination and analysis, sequence comparisons, recombinant expression of His-tagged enzyme in Escherichia coli strain BL21(DE3)pLysS | Mesocricetus auratus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.1.1.51 | C310F | site-directed mutagenesis, the mutation, in analogy to enzyme AKR1C34 sequence, does not affect the enzyme activity of AKR1C35 | Mesocricetus auratus |
1.1.1.51 | V54A | site-directed mutagenesis, the mutation, in analogy to enzyme AKR1C34 sequence, impairs the 3beta-hydroxysteroid dehydrogenase activity of AKR1C35 | Mesocricetus auratus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.51 | 7-hydroxyflavone | - |
Mesocricetus auratus | |
1.1.1.51 | chrysin | - |
Mesocricetus auratus | |
1.1.1.51 | galangin | - |
Mesocricetus auratus | |
1.1.1.51 | genistein | - |
Mesocricetus auratus | |
1.1.1.51 | Hexestrol | - |
Mesocricetus auratus | |
1.1.1.51 | hinokitiol | - |
Mesocricetus auratus | |
1.1.1.51 | lithocholic acid | - |
Mesocricetus auratus | |
1.1.1.51 | Phenolphthalein | - |
Mesocricetus auratus | |
1.1.1.51 | quercetin | - |
Mesocricetus auratus | |
1.1.1.51 | zearalenone | - |
Mesocricetus auratus | |
1.1.1.218 | Hexestrol | - |
Mesocricetus auratus | |
1.1.1.218 | hinokitiol | - |
Mesocricetus auratus | |
1.1.1.218 | additional information | no or poor inhibition by 7-hydroxyflavone, chrysin, quercetin, genistein, galangin, lithocholic acid, and zearalenone | Mesocricetus auratus | |
1.1.1.218 | Phenolphthalein | - |
Mesocricetus auratus | |
1.1.1.239 | Hexestrol | - |
Mesocricetus auratus | |
1.1.1.239 | hinokitiol | - |
Mesocricetus auratus | |
1.1.1.239 | additional information | no or poor inhibition by 7-hydroxyflavone, chrysin, quercetin, genistein, galangin, lithocholic acid, and zearalenone | Mesocricetus auratus | |
1.1.1.239 | Phenolphthalein | - |
Mesocricetus auratus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.51 | additional information | - |
additional information | Michaelis-Menten kinetics | Mesocricetus auratus | |
1.1.1.51 | 0.0004 | - |
17beta-estradiol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.0009 | - |
3beta-hydroxyprogesterone | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.001 | - |
geranylgeraniol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.001 | - |
beta-ionol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.0012 | - |
farnesol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.0012 | - |
(S)-1-indanol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.0015 | - |
(S)-1,2,3,4-tetrahydro-1-naphthol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.0025 | - |
5alpha-Androstan-3beta-ol-17-one | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.0033 | - |
5-androstene-3beta,17beta-diol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.0039 | - |
5beta-androstane-3alpha,17beta-diol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.0039 | - |
5alpha-pregnan-3beta-ol-20-one | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.0041 | - |
geraniol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.0043 | - |
dehydroepiandrosterone | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.0068 | - |
5beta-Pregnan-3beta-ol-20-one | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.0076 | - |
5alpha-dihydrotestosterone | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.0081 | - |
testosterone | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.0081 | - |
4-androstene-3alpha,17beta-diol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.0097 | - |
cis-benzene dihydrodiol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.011 | - |
nerol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.011 | - |
trans-benzene dihydrodiol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.013 | - |
5beta-dihydrotestosterone | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.014 | - |
alpha-3-hydroxyhexobarbital | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.015 | - |
5beta-androstane-3beta,17beta-diol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.015 | - |
5beta-pregnan-3beta,21-diol-20-one | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.017 | - |
NADH | pH 7.4, 25°C, with substrate S-camphorquinone | Mesocricetus auratus | |
1.1.1.51 | 0.023 | - |
1-Acenaphthenol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.023 | - |
NAD+ | pH 7.4, 25°C, with substrate S-tetralol | Mesocricetus auratus | |
1.1.1.51 | 0.026 | - |
2-Cyclohexen-1-ol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.028 | - |
(R)-1,2,3,4-tetrahydro-1-naphthol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.04 | - |
beta-3-hydroxyhexobarbital | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.046 | - |
5beta-androstan-3beta-ol-17-one | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.074 | - |
Cyclohexanol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 2.4 | - |
NADP+ | pH 7.4, 25°C, with substrate S-camphorquinone | Mesocricetus auratus | |
1.1.1.239 | additional information | - |
additional information | Michaelis-Menten kinetics | Mesocricetus auratus | |
1.1.1.239 | 0.0012 | - |
geranylgeraniol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.0097 | - |
beta-ionol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.011 | - |
farnesol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.013 | - |
beta-3-hydroxyhexobarbital | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.013 | - |
NADH | pH 7.4, 25°C, with substrate S-camphorquinone | Mesocricetus auratus | |
1.1.1.239 | 0.013 | - |
NAD+ | pH 7.4, 25°C, with substrate S-tetralol | Mesocricetus auratus | |
1.1.1.239 | 0.03 | - |
alpha-3-hydroxyhexobarbital | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.061 | - |
(S)-1,2,3,4-tetrahydro-1-naphthol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.076 | - |
geraniol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.095 | - |
(R)-1,2,3,4-tetrahydro-1-naphthol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.148 | - |
1-Acenaphthenol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.162 | - |
nerol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.181 | - |
(S)-1-indanol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.569 | - |
2-Cyclohexen-1-ol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.63 | - |
cis-benzene dihydrodiol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 1 | - |
trans-benzene dihydrodiol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 1.38 | - |
NADP+ | pH 7.4, 25°C, with substrate S-camphorquinone | Mesocricetus auratus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.1.1.51 | cytosol | - |
Mesocricetus auratus | 5829 | - |
1.1.1.239 | cytosol | - |
Mesocricetus auratus | 5829 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.1.1.51 | 37000 | - |
x * 37000, recombinant His-tagged enzyme, SDS-PAGE | Mesocricetus auratus |
1.1.1.239 | 37000 | - |
recombinant His-tagged enzyme, SDS-PAGE | Mesocricetus auratus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.218 | morphine + NAD+ | Mesocricetus auratus | - |
? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.51 | Mesocricetus auratus | A0A097ZMZ1 | - |
- |
1.1.1.218 | Mesocricetus auratus | A0A097ZMY7 | - |
- |
1.1.1.239 | Mesocricetus auratus | A0A097ZMY7 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.1.1.51 | recombinant His-tagged wild-type and mutant enzymes from Escherichia coli strain BL21(DE3)pLysS by nickel affinity chromatography, ultrafiltration, and dialysis | Mesocricetus auratus |
1.1.1.218 | recombinant His-tagged enzyme from Escherichia coli strain BL21(DE3)pLysS by nickel affinity chromatography, ultrafiltration, and dialysis | Mesocricetus auratus |
1.1.1.239 | recombinant His-tagged enzyme from Escherichia coli strain BL21(DE3)pLysS by nickel affinity chromatography, ultrafiltration, and dialysis | Mesocricetus auratus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.51 | adrenal gland | in female hamsters | Mesocricetus auratus | - |
1.1.1.51 | brain | in female hamsters | Mesocricetus auratus | - |
1.1.1.51 | colon | in female and male hamsters | Mesocricetus auratus | - |
1.1.1.51 | heart | in female hamsters | Mesocricetus auratus | - |
1.1.1.51 | kidney | in female hamsters | Mesocricetus auratus | - |
1.1.1.51 | liver | - |
Mesocricetus auratus | - |
1.1.1.51 | liver | in female and male hamsters | Mesocricetus auratus | - |
1.1.1.51 | lung | in female hamsters | Mesocricetus auratus | - |
1.1.1.51 | additional information | mRNA for AKR1C34 is expressed liver-specific in male hamsters and ubiquitously in female hamsters | Mesocricetus auratus | - |
1.1.1.51 | ovary | - |
Mesocricetus auratus | - |
1.1.1.51 | small intestine | in female hamsters | Mesocricetus auratus | - |
1.1.1.51 | stomach | in female hamsters | Mesocricetus auratus | - |
1.1.1.51 | testis | in female hamsters | Mesocricetus auratus | - |
1.1.1.218 | adrenal gland | in male hamsters | Mesocricetus auratus | - |
1.1.1.218 | colon | in male hamsters | Mesocricetus auratus | - |
1.1.1.218 | heart | in female hamsters | Mesocricetus auratus | - |
1.1.1.218 | kidney | in male hamsters | Mesocricetus auratus | - |
1.1.1.218 | liver | - |
Mesocricetus auratus | - |
1.1.1.218 | additional information | mRNA for AKR1C34 is expressed liver-specific in female hamsters and ubiquitously in male hamsters | Mesocricetus auratus | - |
1.1.1.218 | small intestine | in male hamsters | Mesocricetus auratus | - |
1.1.1.218 | testis | in male hamsters | Mesocricetus auratus | - |
1.1.1.239 | adrenal gland | in male hamsters | Mesocricetus auratus | - |
1.1.1.239 | colon | in male hamsters | Mesocricetus auratus | - |
1.1.1.239 | heart | in female hamsters | Mesocricetus auratus | - |
1.1.1.239 | kidney | in male hamsters | Mesocricetus auratus | - |
1.1.1.239 | liver | - |
Mesocricetus auratus | - |
1.1.1.239 | additional information | mRNA for AKR1C34 is expressed liver-specific in female hamsters and ubiquitously in male hamsters | Mesocricetus auratus | - |
1.1.1.239 | small intestine | in male hamsters | Mesocricetus auratus | - |
1.1.1.239 | testis | in male hamsters | Mesocricetus auratus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.51 | (R)-1,2,3,4-tetrahydro-1-naphthol + NAD+ | i.e. R-tetralol | Mesocricetus auratus | 3,4-dihydronaphthalen-1(2H)-one + NADH + H+ | - |
? | |
1.1.1.51 | (S)-1,2,3,4-tetrahydro-1-naphthol + NAD+ | i.e. S-tetralol | Mesocricetus auratus | 3,4-dihydronaphthalen-1(2H)-one + NADH + H+ | - |
? | |
1.1.1.51 | (S)-1,2,3,4-tetrahydro-1-naphthol + NADP+ | i.e. S-tetralol | Mesocricetus auratus | 3,4-dihydronaphthalen-1(2H)-one + NADPH + H+ | - |
? | |
1.1.1.51 | (S)-1-indanol + NAD+ | - |
Mesocricetus auratus | 2,3-dihydro-1H-inden-1-one + NADH + H+ | - |
? | |
1.1.1.51 | (S)-camphorquinone + NADH + H+ | - |
Mesocricetus auratus | ? + NAD+ | - |
? | |
1.1.1.51 | (S)-camphorquinone + NADPH + H+ | - |
Mesocricetus auratus | ? + NADP+ | - |
? | |
1.1.1.51 | 1-acenaphthenol + NAD+ | - |
Mesocricetus auratus | acenaphthylen-1(2H)-one + NADH + H+ | - |
? | |
1.1.1.51 | 17beta-estradiol + NAD+ | - |
Mesocricetus auratus | estrone + NADH + H+ | - |
? | |
1.1.1.51 | 2-cyclohexen-1-ol + NAD+ | - |
Mesocricetus auratus | 2-cyclohexen-1-one + NADH + H+ | - |
? | |
1.1.1.51 | 3beta-hydroxyprogesterone + NADH + H+ | - |
Mesocricetus auratus | ? + NAD+ | - |
? | |
1.1.1.51 | 4-androstene-3alpha,17beta-diol + NAD+ | - |
Mesocricetus auratus | ? + NADH + H+ | - |
? | |
1.1.1.51 | 5-androstene-3beta,17beta-diol + NAD+ | - |
Mesocricetus auratus | ? + NADH + H+ | - |
? | |
1.1.1.51 | 5alpha-androstan-3alpha-ol-17-one + NAD+ | - |
Mesocricetus auratus | 5alpha-androstan-3,17-dione + NADH + H+ | - |
? | |
1.1.1.51 | 5alpha-androstan-3beta-ol-17-one + NAD+ | - |
Mesocricetus auratus | 5alpha-androstan-3,17-dione + NADH + H+ | - |
? | |
1.1.1.51 | 5alpha-androstane-3alpha,17beta-diol + NAD+ | - |
Mesocricetus auratus | ? | - |
? | |
1.1.1.51 | 5alpha-dihydrotestosterone + NADH + H+ | - |
Mesocricetus auratus | ? + NAD+ | - |
? | |
1.1.1.51 | 5alpha-pregnan-3alpha-ol-20-one + NAD+ | - |
Mesocricetus auratus | 5alpha-pregnan-3,20-dione + NADH + H+ | - |
? | |
1.1.1.51 | 5alpha-pregnan-3beta-ol-20-one + NAD+ | - |
Mesocricetus auratus | 5alpha-pregnan-3,20-dione + NADH + H+ | - |
? | |
1.1.1.51 | 5beta-androstan-17beta-ol-3-one + NAD+ | - |
Mesocricetus auratus | 5beta-androstan-3,17-dione + NADH + H+ | - |
? | |
1.1.1.51 | 5beta-androstan-3alpha-ol-17-one + NAD+ | - |
Mesocricetus auratus | 5beta-androstan-3,17-dione + NADH + H+ | - |
? | |
1.1.1.51 | 5beta-androstan-3beta-ol-17-one + NADH + H+ | - |
Mesocricetus auratus | ? + NAD+ | - |
? | |
1.1.1.51 | 5beta-androstane-3alpha,17beta-diol + NAD+ | - |
Mesocricetus auratus | ? | - |
? | |
1.1.1.51 | 5beta-androstane-3beta,17beta-diol + NAD+ | - |
Mesocricetus auratus | ? | - |
? | |
1.1.1.51 | 5beta-dihydrotestosterone + NADH + H+ | - |
Mesocricetus auratus | ? + NAD+ | - |
? | |
1.1.1.51 | 5beta-pregnan-20alpha-ol-3-one + NAD+ | - |
Mesocricetus auratus | 5beta-pregnan-3,20-dione + NADH + H+ | - |
? | |
1.1.1.51 | 5beta-pregnan-3beta,21-diol-20-one + NAD+ | - |
Mesocricetus auratus | ? | - |
? | |
1.1.1.51 | 5beta-pregnan-3beta,21-diol-20-one + NADH + H+ | - |
Mesocricetus auratus | ? + NAD+ | - |
? | |
1.1.1.51 | 5beta-pregnan-3beta-ol-20-one + NAD+ | - |
Mesocricetus auratus | 5beta-pregnan-3,20-dione + NADH + H+ | - |
? | |
1.1.1.51 | alpha-3-hydroxyhexobarbital + NAD+ | - |
Mesocricetus auratus | ? | - |
? | |
1.1.1.51 | beta-3-hydroxyhexobarbital + NAD+ | - |
Mesocricetus auratus | ? | - |
? | |
1.1.1.51 | beta-ionol + NAD+ | - |
Mesocricetus auratus | (3E)-4-(2,6,6-trimethylcyclohex-1-en-1-yl)but-3-en-2-one + NADH + H+ | - |
? | |
1.1.1.51 | cis-benzene dihydrodiol + NAD+ | - |
Mesocricetus auratus | ? | - |
? | |
1.1.1.51 | cyclohexanol + NAD+ | - |
Mesocricetus auratus | ? | - |
? | |
1.1.1.51 | dehydroepiandrosterone + NADH + H+ | - |
Mesocricetus auratus | ? + NAD+ | - |
? | |
1.1.1.51 | farnesol + NAD+ | - |
Mesocricetus auratus | farnesal + NADH + H+ | - |
? | |
1.1.1.51 | geraniol + NAD+ | - |
Mesocricetus auratus | geranial + NADH + H+ | - |
? | |
1.1.1.51 | geranylgeraniol + NAD+ | - |
Mesocricetus auratus | geranylgeranial + NADH + H+ | - |
? | |
1.1.1.51 | additional information | the enzyme AKR1C35 efficiently oxidizes various 3beta- and 17beta-hydroxysteroids, including biologically active 3beta-hydroxy-5alpha/beta-dihydro-C19/C21-steroids, dehydroepiandrosterone, and 17beta-estradiol, substrate specificity, detailed overview. Val54 plays a critical role in non-/recognition of the steroidal substrates. Reaction products identification by thin-layer chromatography (TLC) and liquid chromatography/mass spectrometry (LC/MS). No activity with 5beta-pregnan-3alpha-ol-20-one, 3alpha-hydroxyprogesterone, 5beta-androstan-3alpha-ol-17-one, 20alpha-hydroxyprogesterone, and 5alpha-pregnan-20alpha-ol-3-one | Mesocricetus auratus | ? | - |
? | |
1.1.1.51 | nerol + NAD+ | - |
Mesocricetus auratus | neral + NADH + H+ | - |
? | |
1.1.1.51 | testosterone + NAD+ | - |
Mesocricetus auratus | 4-androstenedione + NADH + H+ | - |
? | |
1.1.1.51 | trans-benzene dihydrodiol + NAD+ | - |
Mesocricetus auratus | ? | - |
? | |
1.1.1.218 | additional information | the enzyme AKR1C34 shows 3alpha/17beta/20alpha-hydroxysteroid dehydrogenase activities, EC 1.1.1.239, detailed overview. Ala54 plays a critical role in non-/recognition of the steroidal substrates. Reaction products identification by thin-layer chromatography (TLC) and liquid chromatography/mass spectrometry (LC/MS) | Mesocricetus auratus | ? | - |
? | |
1.1.1.218 | morphine + NAD+ | - |
Mesocricetus auratus | ? | - |
? | |
1.1.1.218 | trans-naphthalene dihydrodiol + NAD+ | - |
Mesocricetus auratus | ? | - |
? | |
1.1.1.239 | (R)-1,2,3,4-tetrahydro-1-naphthol + NAD+ | i.e. (R)-tetralol | Mesocricetus auratus | 3,4-dihydronaphthalen-1(2H)-one + NADH + H+ | - |
? | |
1.1.1.239 | (S)-1,2,3,4-tetrahydro-1-naphthol + NAD+ | i.e. (S)-tetralol | Mesocricetus auratus | 3,4-dihydronaphthalen-1(2H)-one + NADH + H+ | - |
? | |
1.1.1.239 | (S)-1,2,3,4-tetrahydro-1-naphthol + NADP+ | i.e. (S)-tetralol | Mesocricetus auratus | 3,4-dihydronaphthalen-1(2H)-one + NADPH + H+ | - |
? | |
1.1.1.239 | (S)-1-indanol + NAD+ | - |
Mesocricetus auratus | 2,3-dihydro-1H-inden-1-one + NADH + H+ | - |
? | |
1.1.1.239 | (S)-camphorquinone + NADH + H+ | - |
Mesocricetus auratus | ? + NAD+ | - |
? | |
1.1.1.239 | (S)-camphorquinone + NADPH + H+ | - |
Mesocricetus auratus | ? + NADP+ | - |
? | |
1.1.1.239 | 1-acenaphthenol + NAD+ | - |
Mesocricetus auratus | acenaphthylen-1(2H)-one + NADH + H+ | - |
? | |
1.1.1.239 | 17beta-estradiol + NAD+ | - |
Mesocricetus auratus | estrone + NADH + H+ | - |
? | |
1.1.1.239 | 2-cyclohexen-1-ol + NAD+ | - |
Mesocricetus auratus | 2-cyclohexen-1-one + NADH + H+ | - |
? | |
1.1.1.239 | 20alpha-hydroxyprogesterone + NADH + H+ | - |
Mesocricetus auratus | ? + NAD+ | - |
? | |
1.1.1.239 | 3alpha-hydroxyprogesterone + NADH + H+ | - |
Mesocricetus auratus | ? + NAD+ | - |
? | |
1.1.1.239 | 3beta-hydroxyprogesterone + NADH + H+ | - |
Mesocricetus auratus | ? + NAD+ | - |
? | |
1.1.1.239 | 5alpha-androstan-3alpha-ol-17-one + NAD+ | - |
Mesocricetus auratus | 5alpha-androstan-3,17-dione + NADH + H+ | - |
? | |
1.1.1.239 | 5alpha-androstan-3beta-ol-17-one + NAD+ | - |
Mesocricetus auratus | 5alpha-androstan-3,17-dione + NADH + H+ | - |
? | |
1.1.1.239 | 5alpha-androstane-3alpha,17beta-diol + NAD+ | - |
Mesocricetus auratus | ? | - |
? | |
1.1.1.239 | 5alpha-androstane-3beta,17beta-diol + NAD+ | - |
Mesocricetus auratus | ? | - |
? | |
1.1.1.239 | 5alpha-dihydrotestosterone + NAD+ | - |
Mesocricetus auratus | 5alpha-androstane-3,17-dione + NADH + H+ | - |
? | |
1.1.1.239 | 5alpha-pregnan-20alpha-ol-3-one + NAD+ | - |
Mesocricetus auratus | 5alpha-pregnan-3,20-dione + NADH + H+ | - |
? | |
1.1.1.239 | 5alpha-pregnan-3alpha-ol-20-one + NAD+ | - |
Mesocricetus auratus | 5alpha-pregnan-3,20-dione + NADH + H+ | - |
? | |
1.1.1.239 | 5alpha-pregnan-3beta-ol-20-one + NAD+ | - |
Mesocricetus auratus | 5alpha-pregnan-3,20-dione + NADH + H+ | - |
? | |
1.1.1.239 | 5beta-androstan-17beta-ol-3-one + NAD+ | - |
Mesocricetus auratus | 5beta-androstan-3,17-dione + NADH + H+ | - |
? | |
1.1.1.239 | 5beta-androstan-3alpha-ol-17-one + NAD+ | - |
Mesocricetus auratus | 5beta-androstan-3,17-dione + NADH + H+ | - |
? | |
1.1.1.239 | 5beta-androstane-3alpha,17beta-diol + NAD+ | - |
Mesocricetus auratus | ? | - |
? | |
1.1.1.239 | 5beta-androstane-3beta,17beta-diol + NAD+ | - |
Mesocricetus auratus | ? | - |
? | |
1.1.1.239 | 5beta-dihydrotestosterone + NAD+ | - |
Mesocricetus auratus | androstanedione + NADH + H+ | - |
? | |
1.1.1.239 | 5beta-pregnan-20alpha-ol-3-one + NAD+ | - |
Mesocricetus auratus | 5beta-pregnan-3,20-dione + NADH + H+ | - |
? | |
1.1.1.239 | 5beta-pregnan-3alpha-ol-20-one + NAD+ | - |
Mesocricetus auratus | 5beta-pregnan-3,20-dione + NADH + H+ | - |
? | |
1.1.1.239 | 5beta-pregnan-3beta,21-diol-20-one + NAD+ | - |
Mesocricetus auratus | ? | - |
? | |
1.1.1.239 | 5beta-pregnan-3beta-ol-20-one + NAD+ | - |
Mesocricetus auratus | 5beta-pregnan-3,20-dione + NADH + H+ | - |
? | |
1.1.1.239 | alpha-3-hydroxyhexobarbital + NAD+ | - |
Mesocricetus auratus | ? | - |
? | |
1.1.1.239 | beta-3-hydroxyhexobarbital + NAD+ | - |
Mesocricetus auratus | ? | - |
? | |
1.1.1.239 | beta-ionol + NAD+ | - |
Mesocricetus auratus | (3E)-4-(2,6,6-trimethylcyclohex-1-en-1-yl)but-3-en-2-one + NADH + H+ | - |
? | |
1.1.1.239 | cis-benzene dihydrodiol + NAD+ | - |
Mesocricetus auratus | ? | - |
? | |
1.1.1.239 | dehydroepiandrosterone + NAD+ | - |
Mesocricetus auratus | ? + NADH + H+ | - |
? | |
1.1.1.239 | farnesol + NAD+ | - |
Mesocricetus auratus | farnesal + NADH + H+ | - |
? | |
1.1.1.239 | geraniol + NAD+ | - |
Mesocricetus auratus | geranial + NADH + H+ | - |
? | |
1.1.1.239 | geranylgeraniol + NAD+ | - |
Mesocricetus auratus | geranylgeranial + NADH + H+ | - |
? | |
1.1.1.239 | additional information | the enzyme AKR1C34 shows 3alpha/17beta/20alpha-hydroxysteroid dehydrogenase activities, substrate specificity, detailed overview. Ala54 plays a critical role in non-/recognition of the steroidal substrates. Reaction products identification by thin-layer chromatography (TLC) and liquid chromatography/mass spectrometry (LC/MS). AKR1C34 also has morphine dehydrogenase activity, EC 1.1.1.218. No activity with cyclohexanol | Mesocricetus auratus | ? | - |
? | |
1.1.1.239 | nerol + NAD+ | - |
Mesocricetus auratus | neral + NADH + H+ | - |
? | |
1.1.1.239 | testosterone + NAD+ | - |
Mesocricetus auratus | 4-androstenedione + NADH + H+ | - |
? | |
1.1.1.239 | trans-benzene dihydrodiol + NAD+ | - |
Mesocricetus auratus | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.1.1.51 | ? | x * 37000, recombinant His-tagged enzyme, SDS-PAGE | Mesocricetus auratus |
1.1.1.239 | ? | x * 37000, recombinant His-tagged enzyme, SDS-PAGE | Mesocricetus auratus |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.51 | AKR1C35 | - |
Mesocricetus auratus |
1.1.1.51 | LOC101842245 | - |
Mesocricetus auratus |
1.1.1.218 | AKR1C34 | - |
Mesocricetus auratus |
1.1.1.218 | morphine-6-dehydrogenase | UniProt | Mesocricetus auratus |
1.1.1.239 | AKR1C34 | - |
Mesocricetus auratus |
1.1.1.239 | More | cf. EC 1.1.1.218, morphine 6-dehydrogenase | Mesocricetus auratus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.1.1.51 | 25 | - |
assay at | Mesocricetus auratus |
1.1.1.218 | 25 | - |
assay at | Mesocricetus auratus |
1.1.1.239 | 25 | - |
assay at | Mesocricetus auratus |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.51 | 0.0028 | - |
5beta-Pregnan-3beta-ol-20-one | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.0043 | - |
5beta-pregnan-3beta,21-diol-20-one | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.0078 | - |
testosterone | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.008 | - |
geranylgeraniol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.009 | - |
Cyclohexanol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.01 | - |
dehydroepiandrosterone | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.012 | - |
5beta-androstane-3alpha,17beta-diol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.013 | - |
5alpha-pregnan-3beta-ol-20-one | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.018 | - |
farnesol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.018 | - |
alpha-3-hydroxyhexobarbital | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.022 | - |
17beta-estradiol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.022 | - |
1-Acenaphthenol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.022 | - |
5beta-androstan-3beta-ol-17-one | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.022 | - |
beta-ionol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.022 | - |
(R)-1,2,3,4-tetrahydro-1-naphthol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.023 | - |
geraniol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.023 | - |
nerol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.025 | - |
cis-benzene dihydrodiol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.025 | - |
(S)-1,2,3,4-tetrahydro-1-naphthol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.025 | - |
beta-3-hydroxyhexobarbital | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.027 | - |
5alpha-Androstan-3beta-ol-17-one | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.028 | - |
(S)-1-indanol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.032 | - |
5beta-dihydrotestosterone | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.033 | - |
trans-benzene dihydrodiol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.036 | - |
5beta-androstane-3beta,17beta-diol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.04 | - |
2-Cyclohexen-1-ol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.043 | - |
5-androstene-3beta,17beta-diol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.043 | - |
4-androstene-3alpha,17beta-diol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.056 | - |
3beta-hydroxyprogesterone | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.057 | - |
5alpha-dihydrotestosterone | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.1 | - |
NADH | pH 7.4, 25°C, with substrate S-camphorquinone | Mesocricetus auratus | |
1.1.1.51 | 0.11 | - |
NAD+ | pH 7.4, 25°C, with substrate S-tetralol | Mesocricetus auratus | |
1.1.1.51 | 0.15 | - |
NADP+ | pH 7.4, 25°C, with substrate S-camphorquinone | Mesocricetus auratus | |
1.1.1.239 | 0.0045 | - |
farnesol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.0075 | - |
(R)-1,2,3,4-tetrahydro-1-naphthol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.0153 | - |
geraniol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.025 | - |
NAD+ | pH 7.4, 25°C, with substrate S-tetralol | Mesocricetus auratus | |
1.1.1.239 | 0.028 | - |
2-Cyclohexen-1-ol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.032 | - |
cis-benzene dihydrodiol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.038 | - |
geranylgeraniol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.04 | - |
alpha-3-hydroxyhexobarbital | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.045 | - |
trans-benzene dihydrodiol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.053 | - |
beta-ionol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.0917 | - |
NADP+ | pH 7.4, 25°C, with substrate S-camphorquinone | Mesocricetus auratus | |
1.1.1.239 | 0.0967 | - |
beta-3-hydroxyhexobarbital | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.1 | - |
(S)-1-indanol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.105 | - |
(S)-1,2,3,4-tetrahydro-1-naphthol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.115 | - |
nerol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.167 | - |
NADH | pH 7.4, 25°C, with substrate S-camphorquinone | Mesocricetus auratus | |
1.1.1.239 | 0.283 | - |
1-Acenaphthenol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.51 | 9 | - |
substrate oxidation | Mesocricetus auratus |
1.1.1.218 | 7.4 | - |
assay at | Mesocricetus auratus |
1.1.1.239 | 10 | - |
substrate oxidation | Mesocricetus auratus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.51 | additional information | the enzyme shows high preference for NAD+ compared with NADP+ | Mesocricetus auratus | |
1.1.1.51 | NAD+ | conserved residues Gln270 and Glu276 are critical residues for the NAD+ specificity | Mesocricetus auratus | |
1.1.1.51 | NADH | - |
Mesocricetus auratus | |
1.1.1.51 | NADP+ | - |
Mesocricetus auratus | |
1.1.1.51 | NADPH | - |
Mesocricetus auratus | |
1.1.1.239 | additional information | the enzyme shows high preference for NAD+ compared with NADP+ | Mesocricetus auratus | |
1.1.1.239 | NAD+ | conserved residues Gln270 and Glu276 are critical residues for the NAD+ specificity | Mesocricetus auratus | |
1.1.1.239 | NADH | - |
Mesocricetus auratus | |
1.1.1.239 | NADP+ | - |
Mesocricetus auratus | |
1.1.1.239 | NADPH | - |
Mesocricetus auratus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.51 | 0.00011 | - |
chrysin | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.00011 | - |
7-hydroxyflavone | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.00039 | - |
lithocholic acid | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.00046 | - |
quercetin | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.00054 | - |
Hexestrol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.00055 | - |
genistein | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.00069 | - |
galangin | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.0033 | - |
zearalenone | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.1.1.51 | 0.00092 | - |
pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | 7-hydroxyflavone | |
1.1.1.51 | 0.001 | - |
pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | chrysin | |
1.1.1.51 | 0.0026 | - |
pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | quercetin | |
1.1.1.51 | 0.0042 | - |
pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | genistein | |
1.1.1.51 | 0.0044 | - |
pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | lithocholic acid | |
1.1.1.51 | 0.005 | - |
pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | galangin | |
1.1.1.51 | 0.0065 | - |
pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | Hexestrol | |
1.1.1.51 | 0.015 | - |
pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | zearalenone | |
1.1.1.51 | 0.05 | - |
above, pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | Phenolphthalein | |
1.1.1.51 | 0.05 | - |
above, pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | hinokitiol | |
1.1.1.218 | 0.00065 | - |
pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | Phenolphthalein | |
1.1.1.218 | 0.0013 | - |
pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | Hexestrol | |
1.1.1.218 | 0.0032 | - |
pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | hinokitiol | |
1.1.1.239 | 0.00065 | - |
pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | Phenolphthalein | |
1.1.1.239 | 0.0032 | - |
pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | hinokitiol | |
1.1.1.239 | 0.013 | - |
pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | Hexestrol |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.1.1.51 | evolution | enzyme AKR1C35 is a member of the aldoketo reductase (AKR) 1C subfamily in the AKR superfamily | Mesocricetus auratus |
1.1.1.51 | malfunction | mutation of Val54Ala, but not Cys310Phe, significantly impairs the 3beta-hydroxysteroid dehydrogenase enzyme activity, suggesting that Val54 plays a critical role in recognition of the steroidal substrate | Mesocricetus auratus |
1.1.1.51 | physiological function | enzyme AKR1C35 oxidizes various xenobiotic alicyclic alcohols using NAD+ | Mesocricetus auratus |
1.1.1.218 | evolution | enzyme M6DH is a member of the aldoketo reductase (AKR) 1C subfamily in the AKR superfamily | Mesocricetus auratus |
1.1.1.239 | evolution | enzyme AKR1C34 is a member of the aldoketo reductase (AKR) 1C subfamily in the AKR superfamily | Mesocricetus auratus |
1.1.1.239 | physiological function | enzyme AKR1C34 oxidizes various xenobiotic alicyclic alcohols using NAD+ | Mesocricetus auratus |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.51 | 0.063 | - |
NADP+ | pH 7.4, 25°C, with substrate S-camphorquinone | Mesocricetus auratus | |
1.1.1.51 | 0.117 | - |
Cyclohexanol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.28 | - |
5beta-pregnan-3beta,21-diol-20-one | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.42 | - |
5beta-Pregnan-3beta-ol-20-one | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.47 | - |
5beta-androstan-3beta-ol-17-one | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.6 | - |
5beta-dihydrotestosterone | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.63 | - |
beta-3-hydroxyhexobarbital | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.78 | - |
(R)-1,2,3,4-tetrahydro-1-naphthol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 0.95 | - |
1-Acenaphthenol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 1.3 | - |
alpha-3-hydroxyhexobarbital | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 1.55 | - |
2-Cyclohexen-1-ol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 2.17 | - |
nerol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 2.33 | - |
dehydroepiandrosterone | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 2.5 | - |
cis-benzene dihydrodiol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 2.5 | - |
5beta-androstane-3beta,17beta-diol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 2.83 | - |
5alpha-dihydrotestosterone | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 3 | - |
trans-benzene dihydrodiol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 3 | - |
5beta-androstane-3alpha,17beta-diol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 3.33 | - |
5alpha-pregnan-3beta-ol-20-one | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 3.5 | - |
testosterone | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 5 | - |
NAD+ | pH 7.4, 25°C, with substrate S-tetralol | Mesocricetus auratus | |
1.1.1.51 | 5.5 | - |
4-androstene-3alpha,17beta-diol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 5.67 | - |
geraniol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 6 | - |
NADH | pH 7.4, 25°C, with substrate S-camphorquinone | Mesocricetus auratus | |
1.1.1.51 | 7.67 | - |
geranylgeraniol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 9.67 | - |
5-androstene-3beta,17beta-diol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 10.67 | - |
5alpha-Androstan-3beta-ol-17-one | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 14.17 | - |
farnesol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 16.67 | - |
(S)-1,2,3,4-tetrahydro-1-naphthol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 21.67 | - |
beta-ionol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 23.3 | - |
(S)-1-indanol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 63.33 | - |
3beta-hydroxyprogesterone | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.51 | 116.7 | - |
17beta-estradiol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.05 | - |
trans-benzene dihydrodiol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.05 | - |
2-Cyclohexen-1-ol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.05 | - |
cis-benzene dihydrodiol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.067 | - |
nerol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.067 | - |
NADP+ | pH 7.4, 25°C, with substrate S-camphorquinone | Mesocricetus auratus | |
1.1.1.239 | 0.083 | - |
(R)-1,2,3,4-tetrahydro-1-naphthol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.2 | - |
geraniol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.42 | - |
farnesol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 0.55 | - |
(S)-1-indanol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 1.67 | - |
(S)-1,2,3,4-tetrahydro-1-naphthol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 1.83 | - |
1-Acenaphthenol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 2 | - |
NAD+ | pH 7.4, 25°C, with substrate S-tetralol | Mesocricetus auratus | |
1.1.1.239 | 2.17 | - |
alpha-3-hydroxyhexobarbital | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 5.3 | - |
beta-ionol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 7.5 | - |
beta-3-hydroxyhexobarbital | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus | |
1.1.1.239 | 12.67 | - |
NADH | pH 7.4, 25°C, with substrate S-camphorquinone | Mesocricetus auratus | |
1.1.1.239 | 33.3 | - |
geranylgeraniol | pH 7.4, 25°C, recombinant enzyme | Mesocricetus auratus |