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Literature summary extracted from

  • Crnovcic, I.; Vater, J.; Keller, U.
    Occurrence and biosynthesis of C-demethylactinomycins in actinomycin-producing Streptomyces chrysomallus and Streptomyces parvulus (2013), J. Antibiot., 66, 211-218.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.97 ATP + 3-hydroxy-4-methylanthranilate Streptomyces parvulus
-
 diphosphate + 3-hydroxy-4-methylanthranilyl-adenylate
-
 ?
2.7.7.97 ATP + 3-hydroxy-4-methylanthranilate Streptomyces anulatus
-
 diphosphate + 3-hydroxy-4-methylanthranilyl-adenylate
-
 ?
2.7.7.97 ATP + 3-hydroxy-4-methylanthranilate Streptomyces parvulus ATCC 12434
-
 diphosphate + 3-hydroxy-4-methylanthranilyl-adenylate
-
 ?
2.7.7.97 ATP + 3-hydroxy-4-methylanthranilate Streptomyces anulatus ATCC 11523
-
 diphosphate + 3-hydroxy-4-methylanthranilyl-adenylate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.97 Streptomyces anulatus
-
-
-
2.7.7.97 Streptomyces anulatus ATCC 11523
-
-
-
2.7.7.97 Streptomyces parvulus
-
-
-
2.7.7.97 Streptomyces parvulus ATCC 12434
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.97 mycelium
-
 Streptomyces parvulus
-
2.7.7.97 mycelium
-
 Streptomyces anulatus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.97 ATP + 3-hydroxy-4-methylanthranilate
-
 Streptomyces parvulus diphosphate + 3-hydroxy-4-methylanthranilyl-adenylate
-
 ?
2.7.7.97 ATP + 3-hydroxy-4-methylanthranilate
-
 Streptomyces anulatus diphosphate + 3-hydroxy-4-methylanthranilyl-adenylate
-
 ?
2.7.7.97 ATP + 3-hydroxy-4-methylanthranilate
-
 Streptomyces parvulus ATCC 12434 diphosphate + 3-hydroxy-4-methylanthranilyl-adenylate
-
 ?
2.7.7.97 ATP + 3-hydroxy-4-methylanthranilate
-
 Streptomyces anulatus ATCC 11523 diphosphate + 3-hydroxy-4-methylanthranilyl-adenylate
-
 ?
2.7.7.97 ATP + 3-hydroxyanthranilic acid much lower catalytic efficiency with 3-hydroxyanthranilic acid compared to 3-hydroxy-4-methylanthranilate Streptomyces parvulus ?
-
 ?
2.7.7.97 ATP + 3-hydroxyanthranilic acid much lower catalytic efficiency with 3-hydroxyanthranilic acid compared to 3-hydroxy-4-methylanthranilate Streptomyces anulatus ?
-
 ?
2.7.7.97 ATP + 3-hydroxyanthranilic acid much lower catalytic efficiency with 3-hydroxyanthranilic acid compared to 3-hydroxy-4-methylanthranilate Streptomyces parvulus ATCC 12434 ?
-
 ?
2.7.7.97 ATP + 3-hydroxyanthranilic acid much lower catalytic efficiency with 3-hydroxyanthranilic acid compared to 3-hydroxy-4-methylanthranilate Streptomyces anulatus ATCC 11523 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.97 4-MHA activating enzyme
-
 Streptomyces parvulus
2.7.7.97 4-MHA activating enzyme
-
 Streptomyces anulatus
2.7.7.97 ACMS I
-
 Streptomyces parvulus
2.7.7.97 ACMS I
-
 Streptomyces anulatus
2.7.7.97 actinomycin synthetase I
-
 Streptomyces parvulus
2.7.7.97 actinomycin synthetase I
-
 Streptomyces anulatus

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
2.7.7.97 0.3
-
 3-hydroxyanthranilic acid at 30°C, pH not specified in the publication Streptomyces parvulus
2.7.7.97 0.3
-
 3-hydroxyanthranilic acid at 30°C, pH not specified in the publication Streptomyces anulatus
2.7.7.97 7.8
-
 3-hydroxy-4-methylanthranilate at 30°C, pH not specified in the publication Streptomyces parvulus
2.7.7.97 7.8
-
 3-hydroxy-4-methylanthranilate at 30°C, pH not specified in the publication Streptomyces anulatus