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Literature summary extracted from

  • Lalle, M.; Camerini, S.; Cecchetti, S.; Finelli, R.; Sferra, G.; Mueller, J.; Ricci, G.; Pozio, E.
    The FAD-dependent glycerol-3-phosphate dehydrogenase of Giardia duodenalis: an unconventional enzyme that interacts with the g14-3-3 and it is a target of the antitumoral compound NBDHEX (2015), Front. Microbiol., 6, 544.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.5.3 expressed in Escherichia coli BL21(DE3) cells Giardia intestinalis

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.5.3 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol
-
Giardia intestinalis
1.1.5.3 metronidazole
-
Giardia intestinalis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.5.3 mitochondrion
-
Giardia intestinalis 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.5.3 119000
-
-
Giardia intestinalis
1.1.5.3 120000
-
x * 120000, SDS-PAGE Giardia intestinalis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.5.3 sn-glycerol 3-phosphate + a quinone Giardia intestinalis
-
glycerone phosphate + a quinol
-
?
1.1.5.3 sn-glycerol 3-phosphate + a quinone Giardia intestinalis WB-C6
-
glycerone phosphate + a quinol
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.1.5.3 Giardia intestinalis
-
-
-
1.1.5.3 Giardia intestinalis WB-C6
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.5.3 nickel resin column chromatography Giardia intestinalis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.5.3 sn-glycerol 3-phosphate + a quinone
-
Giardia intestinalis glycerone phosphate + a quinol
-
?
1.1.5.3 sn-glycerol 3-phosphate + a quinone
-
Giardia intestinalis WB-C6 glycerone phosphate + a quinol
-
?
1.1.5.3 sn-glycerol 3-phosphate + phenazine methosulfate
-
Giardia intestinalis ?
-
?
1.1.5.3 sn-glycerol 3-phosphate + phenazine methosulfate
-
Giardia intestinalis WB-C6 ?
-
?

Subunits

EC Number Subunits Comment Organism
1.1.5.3 ? x * 120000, SDS-PAGE Giardia intestinalis
1.1.5.3 ? x * 119000, calculated from amino acid sequence Giardia intestinalis

Synonyms

EC Number Synonyms Comment Organism
1.1.5.3 FAD-dependent glycerol-3-phosphate dehydrogenase
-
Giardia intestinalis
1.1.5.3 flavin adenine dinucleotide-dependent glycerol-3-phosphate dehydrogenase
-
Giardia intestinalis
1.1.5.3 G3PD
-
Giardia intestinalis

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.5.3 FAD
-
Giardia intestinalis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.5.3 0.0006
-
at pH 7.5 and 25°C Giardia intestinalis 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol
1.1.5.3 0.0019
-
at pH 7.5 and 25°C Giardia intestinalis metronidazole

General Information

EC Number General Information Comment Organism
1.1.5.3 physiological function the enzyme is involved in glycolysis, electron transport, glycerophospholipids metabolism, and hyperosmotic stress response Giardia intestinalis