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Literature summary extracted from

  • de Bari, L.; Moro, L.; Passarella, S.
    Prostate cancer cells metabolize D-lactate inside mitochondria via a D-lactate dehydrogenase which is more active and highly expressed than in normal cells (2013), FEBS Lett., 587, 467-473.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.2.4 oxalate
-
Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.2.4 mitochondrial inner membrane the enzyme is located on the inner face of the inner mitochondrial membrane Homo sapiens 5743
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.2.4 (R)-lactate + 2 ferricytochrome c Homo sapiens
-
pyruvate + 2 ferrocytochrome c
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.1.2.4 Homo sapiens Q86WU2
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.2.4 PC-3 cell
-
Homo sapiens
-
1.1.2.4 PNT-1A cell
-
Homo sapiens
-
1.1.2.4 prostate cancer cell
-
Homo sapiens
-
1.1.2.4 prostate gland
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.2.4 (R)-lactate + 2 ferricytochrome c
-
Homo sapiens pyruvate + 2 ferrocytochrome c
-
?
1.1.2.4 additional information D-LDH activity assay and (R)-lactate-dependent cyt c and flavin reduction Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
1.1.2.4 D-LDH
-
Homo sapiens
1.1.2.4 DLD
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.2.4 37
-
assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.2.4 7.5
-
assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.2.4 FAD the enzyme is a flavoprotein. The flavin/pyridine cofactor redox state is detected fluorimetrically in cell homogenates Homo sapiens
1.1.2.4 ferricytochrome c
-
Homo sapiens

General Information

EC Number General Information Comment Organism
1.1.2.4 metabolism prostate cancer cells metabolize D-lactate inside mitochondria via a D-lactate dehydrogenase which is more active and highly expressed than in normal cells. D-Lactate can enter prostate mitochondria and cause the export of newly synthesized malate in a carrier-mediated manner, with the rate of malate efflux from mitochondria being twofold higher in cancer compared to healthy cells, overview Homo sapiens
1.1.2.4 physiological function the mitochondrial D-lactate dehydrogenase, a membrane flavoprotein, from both cancer (PC-3) and normal (PNT1A) prostate cells can metabolize D-lactate in an energy competent manner Homo sapiens