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Literature summary extracted from

  • Fujino, T.; Kang, M.J.; Suzuki, H.; Iijima, H.; Yamamoto, T.
    Molecular characterization and expression of rat acyl-CoA synthetase 3 (1996), J. Biol. Chem., 271, 16748-16752.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.2.1.3 ACS3, one of multiple forms of enzyme in brain, expression in COS cells Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.2.1.3 0.00053
-
 CoA
-
 Rattus norvegicus
6.2.1.3 0.5
-
 ATP
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.3 ATP + long-chain carboxylic acid + CoA Rattus norvegicus the presence in the brain of multiple forms of enzyme with different fatty acid specificity is of considerable biological significance for controlling the synthesis of brain lipids. ACS3 mRNA is detectable 5 days after birth, increases to a maximum level at 15 days, and then decreases gradually to 10% of its maximum level in the adult ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.3 Rattus norvegicus Q63151 ACS3, one of multiple form of the enzyme in brain
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.2.1.3 ACS3, one of multiple forms of enzyme in brain Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.3 adrenal gland low activity Rattus norvegicus
-
6.2.1.3 brain most abundant in Rattus norvegicus
-
6.2.1.3 kidney low activity Rattus norvegicus
-
6.2.1.3 lung low activity Rattus norvegicus
-
6.2.1.3 small intestine low activity Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.2.1.3 4.62
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.3 ATP + arachidonate + CoA
-
 Rattus norvegicus AMP + diphosphate + arachidonoyl-CoA
-
 ?
6.2.1.3 ATP + eicosapentaenoate + CoA
-
 Rattus norvegicus AMP + diphosphate + eicosapentaenoyl-CoA
-
 ?
6.2.1.3 ATP + laurate + CoA
-
 Rattus norvegicus AMP + diphosphate + lauroyl-CoA
-
 ?
6.2.1.3 ATP + long-chain carboxylic acid + CoA utilizes laurate and myristate most efficientyl among C8-C22 saturated fatty acids and arachidonate and eicosapentaenoate among the C16-C20 unsaturated fatty acids Rattus norvegicus AMP + diphosphate + long-chain acyl-CoA
-
 ?
6.2.1.3 ATP + long-chain carboxylic acid + CoA the presence in the brain of multiple forms of enzyme with different fatty acid specificity is of considerable biological significance for controlling the synthesis of brain lipids. ACS3 mRNA is detectable 5 days after birth, increases to a maximum level at 15 days, and then decreases gradually to 10% of its maximum level in the adult Rattus norvegicus ?
-
 ?
6.2.1.3 ATP + myristate + CoA
-
 Rattus norvegicus AMP + diphosphate + myristoyl-CoA
-
 ?
6.2.1.3 ATP + palmitate + CoA
-
 Rattus norvegicus AMP + diphosphate + palmitoyl-CoA
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.2.1.3 7.5 8.5
-
 Rattus norvegicus