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Literature summary extracted from

  • Tsurumaru, Y.; Sasaki, K.; Miyawaki, T.; Uto, Y.; Momma, T.; Umemoto, N.; Momose, M.; Yazaki, K.
    HlPT-1, a membrane-bound prenyltransferase responsible for the biosynthesis of bitter acids in hops (2012), Biochem. Biophys. Res. Commun., 417, 393-398.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.5.1.136 chloroplast
-
 Humulus lupulus 9507
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.5.1.136 Mg2+ exclusive requirement for Mg2+ Humulus lupulus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.136 dimethylallyl diphosphate + naringenin chalcone Humulus lupulus
-
 diphosphate + desmethylxanthohumol
-
 ?
2.5.1.136 dimethylallyl diphosphate + phlorisobutyrophenone Humulus lupulus 61.9% of the activity with phlorisovalerophenone diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one
-
 ?
2.5.1.136 dimethylallyl diphosphate + phlorisovalerophenone Humulus lupulus best substrate diphosphate + 3-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one
-
 ?
2.5.1.136 dimethylallyl diphosphate + phlormethylbutanophenone Humulus lupulus 29.5% of the activity with phlorisovalerophenone diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]butan-1-one
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.136 Humulus lupulus E5RP65
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.136 dimethylallyl diphosphate + naringenin chalcone
-
 Humulus lupulus diphosphate + desmethylxanthohumol
-
 ?
2.5.1.136 dimethylallyl diphosphate + phlorisobutyrophenone 61.9% of the activity with phlorisovalerophenone Humulus lupulus diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one
-
 ?
2.5.1.136 dimethylallyl diphosphate + phlorisovalerophenone best substrate Humulus lupulus diphosphate + 3-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one
-
 ?
2.5.1.136 dimethylallyl diphosphate + phlormethylbutanophenone 29.5% of the activity with phlorisovalerophenone Humulus lupulus diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]butan-1-one
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.136 aromatic prenyltransferase
-
 Humulus lupulus
2.5.1.136 PT-1
-
 Humulus lupulus
2.5.1.136 PT1
-
 Humulus lupulus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.5.1.136 7
-
 narrow Humulus lupulus

General Information

EC Number General Information Comment Organism
2.5.1.136 physiological function PT-1 catalyzes the first transfer of dimethylallyl moiety to phloroglucinol derivatives, phlorisovalerophenone, phlorisobutyrophenone and phlormethylbutanophenone, leading to the formation of humulone and lupulone derivatives, i.e. Humulus lupulus bitter acids. PT-1 also recognizes naringenin chalcone as a flavonoid substrate to yield xanthohumol Humulus lupulus