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Literature summary extracted from

  • Jordan, C.A.; Sandoval, B.A.; Serobyan, M.V.; Gilling, D.H.; Groziak, M.P.; Xu, H.H.; Vey, J.L.
    Crystallographic insights into the structure-activity relationships of diazaborine enoyl-ACP reductase inhibitors (2015), Acta Crystallogr. Sect. F, 71, 1521-1530.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.9 expressed in Escherichia coli BL21(DE3) cells Escherichia coli

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.3.1.9 hanging drop vapor diffusion method, using 100 mM citrate pH 7.0, 100 mM ammonium sulfate, 22% (w/v) PEG 3350 Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.9 1-hydroxy-2,3,1-benzodiazaborinine-2(1H)-carbothioamide
-
 Escherichia coli
1.3.1.9 2-(toluene-4-sulfonyl)-2H-benzo[d][1,2,3]diazaborinin-1-ol
-
 Escherichia coli
1.3.1.9 2-methylsulfonyl-6-methylbenzodiazaborine
-
 Escherichia coli
1.3.1.9 2-methylsulfonyl-benzodiazaborine
-
 Escherichia coli
1.3.1.9 2-[amino(hydroxy)methyl]-2,3,1-benzodiazaborinin-1(2H)-ol
-
 Escherichia coli
1.3.1.9 5,11-dimethyl-8H-[2,3,1]benzodiazaborinino[2',1':5,6][1,3,5,2,6]oxadiazadiborinino[2,3-a][2,3,1]benzodiazaborinin-8-one
-
 Escherichia coli
1.3.1.9 6-methyl-2(propane-1-sulfonyl)-2H-thieno[3,2-d][1,2,3]diazaborinin-1-ol
-
 Escherichia coli
1.3.1.9 diazaborine
-
 Escherichia coli
1.3.1.9 triclosan
-
 Escherichia coli
1.3.1.9 [oxydi(2,3,1-benzodiazaborinine-1,2-diyl)]bis[(pyridin-4-yl)methanone]
-
 Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.9 Escherichia coli P0AEK4
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.9 HisTrap column chromatography Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.9 crotonyl-CoA + NADH + H+
-
 Escherichia coli butyryl-CoA + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.9 enoyl-ACP reductase
-
 Escherichia coli
1.3.1.9 enoyl-acyl carrier protein reductase
-
 Escherichia coli
1.3.1.9 ENR
-
 Escherichia coli
1.3.1.9 FabI
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.9 NADH
-
 Escherichia coli