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Literature summary extracted from

  • Khomutov, M.; Keinanen, T.; Hyvonen, M.; Weisell, J.; Vepsalainen, J.; Alhonen, L.; Kochetkov, S.; Khomutov, A.
    Enantioselective synthesis of (R)- and (S)-3-methylspermidines (2015), Russ. J. Bioorg. Chem., 41, 548-553.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.46 [eIF5A-precursor]-lysine + spermidine Homo sapiens
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 [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.46 Homo sapiens P49366
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.46 DU-145 cell
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 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.46 additional information (R)-3-methylspermidine competes with spermidine for cellular uptake less efficiently than the (S)-3-methylspermidine Homo sapiens ?
-
 ?
2.5.1.46 [eIF5A-precursor]-lysine + (R)-3-methylspermidine no activity with the (S)-enantiomer Homo sapiens ?
-
 ?
2.5.1.46 [eIF5A-precursor]-lysine + spermidine
-
 Homo sapiens [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?
2.5.1.46 [eIF5A-precursor]-lysine + spermidine formation of [N(epsilon)-(4-amino-2-hydroxybutyl)lysine] Homo sapiens [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.46 DHS
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.5.1.46 additional information the inability of racemic 3-methylspermidine and (S)-3-methylspermidine to support DU-145 cells growth due to the fact that only the (R)-isomer is a substrate of DHS, but this isomer, (R)-3-methylspermidine, competes with spermidine for cellular uptake and is less efficient than the (S)-3-methylspermidine, which results in accumulation of inactive (S)-3-methylspermidine in the cell. Synthesis of (S)-3-methylspermidine and (R)-3-methylspermidine, overview Homo sapiens