EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.2.4.4 | (S)-2-chlorophenylpropionic acid | - |
Mus musculus |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.7.11.4 | in complex with (S)-alpha-chloro-phenylpropionic acid, hanging drop vapor diffusion method, using 12% (w/v) PEG-8000, 0.1 M Tris·HCl, pH 8.5, 1.3-1.5 M NaCl | Mus musculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.2.4.4 | (S)-2-chloro-phenylpropionic acid | - |
Mus musculus | |
2.7.11.4 | (2R)-2-chloro-3-phenylpropanoic acid | - |
Mus musculus | |
2.7.11.4 | (2S)-2-chloro-3-phenylpropanoic acid | - |
Mus musculus | |
2.7.11.4 | (R)-alpha-chloroisocaproate | - |
Mus musculus | |
2.7.11.4 | (S)-alpha-chloroisocaproate | - |
Mus musculus | |
2.7.11.4 | 2-oxoisocaproate | - |
Mus musculus | |
2.7.11.4 | Clofibric acid | - |
Mus musculus | |
2.7.11.4 | Hydrocinnamic acid | - |
Mus musculus | |
2.7.11.4 | methylhydrocinnamic acid | - |
Mus musculus | |
2.7.11.4 | phenylacetate | - |
Mus musculus | |
2.7.11.4 | phenylbutyrate | - |
Mus musculus | |
2.7.11.4 | phenylpyruvic acid | - |
Mus musculus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.7.11.4 | mitochondrion | - |
Mus musculus | 5739 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.4.4 | 2-oxoisocaproate + NAD+ + CoA | Mus musculus | - |
3-methylbutanoyl-CoA + CO2 + NADH + H+ | - |
? | |
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] | Mus musculus | - |
ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.4.4 | Mus musculus | - |
- |
- |
2.7.11.4 | Mus musculus | O55028 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.2.4.4 | muscle | - |
Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.4.4 | 2-oxoisocaproate + NAD+ + CoA | - |
Mus musculus | 3-methylbutanoyl-CoA + CO2 + NADH + H+ | - |
? | |
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] | - |
Mus musculus | ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.2.4.4 | BCKDC | - |
Mus musculus |
1.2.4.4 | branched-chain alpha-ketoacid dehydrogenase | - |
Mus musculus |
2.7.11.4 | BCKD kinase | - |
Mus musculus |
2.7.11.4 | BDK | - |
Mus musculus |
2.7.11.4 | branched-chain alpha-ketoacid dehydrogenase kinase | - |
Mus musculus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.2.4.4 | NAD+ | - |
Mus musculus |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.7.11.4 | 0.0063 | - |
at pH 7.5 and 25°C | Mus musculus | (2S)-2-chloro-3-phenylpropanoic acid | |
2.7.11.4 | 0.012 | - |
at pH 7.5 and 25°C | Mus musculus | (R)-alpha-chloroisocaproate | |
2.7.11.4 | 0.0214 | - |
at pH 7.5 and 25°C | Mus musculus | (2R)-2-chloro-3-phenylpropanoic acid | |
2.7.11.4 | 0.0338 | - |
at pH 7.5 and 25°C | Mus musculus | methylhydrocinnamic acid | |
2.7.11.4 | 0.0431 | - |
at pH 7.5 and 25°C | Mus musculus | Hydrocinnamic acid | |
2.7.11.4 | 0.0531 | - |
at pH 7.5 and 25°C | Mus musculus | phenylbutyrate | |
2.7.11.4 | 0.0534 | - |
at pH 7.5 and 25°C | Mus musculus | (S)-alpha-chloroisocaproate | |
2.7.11.4 | 0.0749 | - |
at pH 7.5 and 25°C | Mus musculus | 2-oxoisocaproate | |
2.7.11.4 | 0.346 | - |
at pH 7.5 and 25°C | Mus musculus | phenylpyruvic acid | |
2.7.11.4 | 0.812 | - |
at pH 7.5 and 25°C | Mus musculus | Clofibric acid | |
2.7.11.4 | 1.27 | - |
at pH 7.5 and 25°C | Mus musculus | phenylacetate |